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Neural substrates for the functional shift of neural circuit during learning

Research Project

Project/Area Number 17K13114
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Developmental mechanisms and the body works
Research InstitutionFukushima Medical University

Principal Investigator

Setogawa Susumu  福島県立医科大学, 医学部, 博士研究員 (30760508)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords学習 / 習慣形成 / 手続き記憶 / 大脳基底核 / 運動スキル / 意思決定 / 知覚運動学習 / 目標指向性行動 / 線条体 / 小脳 / 知覚-運動学習 / 柔軟な意思決定
Outline of Final Research Achievements

To reveal the neural mechanisms underlying the habit formation, we performed behavioral, pharmacological, and small-animal neuroimaging analysis using rats. This study suggests that the dorsal striatum and cerebellum contribute to the habitual learning and outputs of learned behavior respectively.

Academic Significance and Societal Importance of the Research Achievements

習慣形成に関わる神経基盤の破綻は、薬物依存症など様々な疾患と関与することが分かっている。そのため、本研究成果は依存症等の精神疾患に対する新たな治療法の開発や発症メカニズムの解明に向けて基礎的知見を提供しうるものと期待できる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (12 results)

All 2019 2018 2017 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (9 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Remarks (1 results)

  • [Journal Article] Motor skills mediated through cerebellothalamic tracts projecting to the central lateral nucleus2019

    • Author(s)
      Sakayori Nobuyuki、Kato Shigeki、Sugawara Masateru、Setogawa Susumu、Fukushima Hotaka、Ishikawa Rie、Kida Satoshi、Kobayashi Kazuto
    • Journal Title

      Molecular Brain

      Volume: 12 Issue: 13 Pages: 13-13

    • DOI

      10.1186/s13041-019-0431-x

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 運動・認知スキルの学習基盤としての線条体2018

    • Author(s)
      瀬戸川将
    • Journal Title

      バイオメカニクス研究

      Volume: 22 Pages: 65-72

    • Related Report
      2018 Research-status Report
  • [Presentation] Dynamic shifts of striatal activation pattern during acquisition of an auditory discrimination task2018

    • Author(s)
      Setogawa, S., Okauchi, T., Hu, D., Shigeta, M., Hayashinaka, E., Onoe, K., Wada, Y., Hikishima, K., Onoe, H., Cui, YL., Kobayashi, K.,
    • Organizer
      Neuroscience 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 聴覚弁別行動の獲得過程における線条体内の機能シフト2018

    • Author(s)
      瀬戸川将
    • Organizer
      次世代脳プロジェクト冬のシンポジウム2018
    • Related Report
      2018 Research-status Report
  • [Presentation] The functional shift of striatal circuits during an acquisition of auditory discrimination2018

    • Author(s)
      瀬戸川将
    • Organizer
      平成30年度第2回大脳基底核研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 線条体における学習依存的な神経回路シフトの解明2018

    • Author(s)
      瀬戸川将,加藤成樹,小林和人
    • Organizer
      第33回日本大脳基底核研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 腹側被蓋野破壊が歩行時の障害物回避動作へ及ぼす影響2018

    • Author(s)
      瀬戸川将,柳原大
    • Organizer
      第16回姿勢と歩行研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] 小動物脳機能イメージング法を用いた行動の習慣化における脳活動の網羅的解析2017

    • Author(s)
      瀬戸川将,岡内隆,井口善生,和田康弘,林中恵美,疋島啓吾,崔翼龍,小林和人
    • Organizer
      次世代脳プロジェクト冬のシンポジウム2017
    • Related Report
      2017 Research-status Report
  • [Presentation] Development of improved viral vectors for the pathway-specific manipulation and analysis of the brain areas activated during the auditory discrimination learning2017

    • Author(s)
      Susumu Setogawa, Shigeki Kato., Yoshio Iguchi, Inoue K., Masahiko Takada, Keigo Hikishima, Ylong Cui, Hirotaka Onoe, and Kazuto Kobayashi
    • Organizer
      International symposium on Adaptive circuit shift
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 知覚-運動学習の過剰訓練による脳活動領域の動的シフト2017

    • Author(s)
      瀬戸川将,岡内隆,胡迪,重田美香、疋島啓吾,崔翼龍,小林和人
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 経路選択的操作へ 向けたウイルスベクターの性能向上と聴覚弁別学習の獲得プロセスにおける神経活動領域の解析2017

    • Author(s)
      瀬戸川 将, 加藤 成樹, 井口 善生, 井上 謙一, 高田 昌彦, 崔 翼龍, 尾上 浩隆, 小林和人
    • Organizer
      適応回路シフト・領域班会議
    • Related Report
      2017 Research-status Report
  • [Remarks] Templates for Long-Evans Rat Brain

    • URL

      https://www.nitrc.org/projects/tpm_rat/

    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2022-12-28  

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