Neural substrates for the functional shift of neural circuit during learning
| Project/Area Number |
17K13114
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental mechanisms and the body works
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
Setogawa Susumu 福島県立医科大学, 医学部, 博士研究員 (30760508)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 学習 / 習慣形成 / 手続き記憶 / 大脳基底核 / 運動スキル / 意思決定 / 知覚運動学習 / 目標指向性行動 / 線条体 / 小脳 / 知覚－運動学習 / 柔軟な意思決定 |
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| Outline of Final Research Achievements |
To reveal the neural mechanisms underlying the habit formation, we performed behavioral, pharmacological, and small-animal neuroimaging analysis using rats. This study suggests that the dorsal striatum and cerebellum contribute to the habitual learning and outputs of learned behavior respectively.
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| Academic Significance and Societal Importance of the Research Achievements |
習慣形成に関わる神経基盤の破綻は、薬物依存症など様々な疾患と関与することが分かっている。そのため、本研究成果は依存症等の精神疾患に対する新たな治療法の開発や発症メカニズムの解明に向けて基礎的知見を提供しうるものと期待できる。
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Report
(4 results)
Research Products
(12 results)
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[Presentation] Dynamic shifts of striatal activation pattern during acquisition of an auditory discrimination task2018
Author(s)
Setogawa, S., Okauchi, T., Hu, D., Shigeta, M., Hayashinaka, E., Onoe, K., Wada, Y., Hikishima, K., Onoe, H., Cui, YL., Kobayashi, K.,
Organizer
Neuroscience 2018
Related Report
Int'l Joint Research
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