• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Genetics and response to physical training

Research Project

Project/Area Number 17K13152
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Sports science
Research InstitutionNippon Sport Science University

Principal Investigator

KIKUCHI Naoki  日本体育大学, 体育学部, 准教授 (10739478)

Research Collaborator Fuku Noriyuki  
Nakazato Koichi  
Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords筋力トレーニング / 遺伝子多型 / トレーニング効果 / ACTN3 / ACE / MCT1 / 筋肥大 / 筋力 / 損傷 / パフォーマンス / アスリート / スポーツ損傷 / データベース
Outline of Final Research Achievements

We investigated whether the gene polymorphisms (ACTN3 R577X, ACE I/D, MCT1 T1470A) affects athletic performance and Injury in Japanese cohort and the effect of gene polymorphisms on response to resistance training. we found some relationship between ACTN3 R577X and MCT1 T1470A and athletic performance and muscle phenotype. However, we found no significant difference of response to 8 weeks of moderate load resistance training. Sample size is very small in this study. future study is necessary to conform the effect of genetic information on response to physical training, such as resistance training and endurance training.

Academic Significance and Societal Importance of the Research Achievements

現在、遺伝子多型を解析するサービスを提供する企業が多く存在する。一方で、遺伝子多型がスポーツパフォーマンスやトレーニング反応に影響するという科学的根拠は不十分である。本研究では、横断的な大規模研究では遺伝子多型の影響が認められたものの、貢献度は3-5%%と非常に低い。さらに、46名の対象者を検討した継続的なトレーニング効果については遺伝子多型による影響はみられなかった。今後、さらなる検討を行い遺伝子情報の活用について慎重に行う必要がある。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (11 results)

All 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results) Remarks (2 results)

  • [Int'l Joint Research] Cagliari University(イタリア)

    • Related Report
      2017 Research-status Report
  • [Journal Article] ESR1 rs2234693 Polymorphism Is Associated with Muscle Injury and Muscle Stiffness2018

    • Author(s)
      Hiroshi Kumagai、Eri Miyamoto-Mikami、Kosuke Hirata、Naoki Kikuchi、Nobuhiro Kamiya、Seigo Hoshikawa、Hirofumi Zempo、Hisashi Naito、Naokazu Miyamoto、Noriyuki Fuku
    • Journal Title

      Medicine & Science in Sports & Exercise

      Volume: 1 Issue: 1 Pages: 19-26

    • DOI

      10.1249/mss.0000000000001750

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] AGTR2 and sprint/power performance: a case-control replicationstudy for rs11091046 polymorphism in two ethnicities2018

    • Author(s)
      Yvert TP、Zempo H、Gabdrakhmanova LJ、Kikuchi N、Miyamoto-Mikami E、Murakami H、Naito H、Miyachi M、Fuku N et al.
    • Journal Title

      Biology of Sport

      Volume: - Issue: 2 Pages: 105-109

    • DOI

      10.5114/biolsport.2018.71599

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of ACTN3 on the strength and flexibility before and after eccentric contractions2018

    • Author(s)
      Kikuchi N, Tsuchiya Y, Nakazato K, Ishii N, Ochi E.
    • Journal Title

      International Journal of Sports Medicine

      Volume: 39 Issue: 02 Pages: 148-153

    • DOI

      10.1055/s-0043-120762

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Heritability estimates of endurance-related phenotypes: A systematic review and meta-analysis.2018

    • Author(s)
      Miyamoto-Mikami E, Zempo H, Fuku N, Kikuchi N, Miyachi M, Murakami H.
    • Journal Title

      Scandinavian Journal of Medicine and Science in Sports.

      Volume: 28 Issue: 3 Pages: 834-845

    • DOI

      10.1111/sms.12958

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of COL11A1 4603C/T polymorphism with cervical disc degeneration in collegiate wrestlers.2017

    • Author(s)
      Koyama K, Nakazato K, Maeda S, Kikuchi N, Matsumoto S, Hiranuma K.
    • Journal Title

      Journal of Sports Medicine and Physical Fitness

      Volume: 印刷中 Issue: 11

    • DOI

      10.23736/s0022-4707.17.07724-6

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between ACTN3 R577X polymorphism and trunk flexibility in tow different cohorts.2017

    • Author(s)
      Kikuchi N, Zempo H, Fuku N, Murakami H, Sakamaki-Sunaga M, Okamoto T, Nakazato K, Miyachi M.
    • Journal Title

      International Journal Sports Medicine

      Volume: 38 Issue: 05 Pages: 402-406

    • DOI

      10.1055/s-0042-118649

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Association between ACTN3 R577X polymorphism and weight-lifting performance in Japanese and Italian atheltes.2018

    • Author(s)
      Naoki Kikuchi, Myosotis Massidda, Tatsuru Miyamae, Shunsuke Suzuki, Akihiro Inoue, Naoyuki Kobatake, Daniele Masala, Carla M. Calo’ CM, Koichi Nakazato4
    • Organizer
      American Collage od Sports Medicine
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ALDH2 rs671 polymorphism is associated with athletic status and muscle phenotypes in the Japanese population2018

    • Author(s)
      Naoki Kikuchi、Takafumi Tajima、Yoshiaki Yamanaka、Kunitaka Menuki、Takanobu Okamoto, Mikako Sakamaki-Sunaga, Akinori Sakai、Kenji Hiranuma、Koichi Nakazato
    • Organizer
      Experimental Biology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Remarks] KIKULAB S&C Research team

    • URL

      http://kikulab-nssu.com

    • Related Report
      2018 Annual Research Report
  • [Remarks] 日体大菊池研究室ホームページ

    • URL

      http://kikulab-nssu.com

    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi