Research Project
Grant-in-Aid for Young Scientists (B)
Motor learning reduces the trial-to-trial variability in neural responses during the learned behavior, but little is known how neurons generate the stable responses during the movement. In this research project, we developed a protocol to train mouse to use forelimbs to pull a lever, and also developed methods to measure the response and synaptic inputs from the same neuron during the task performance by combining cell-attached recording/two-photon imaging and whole-cell recording. Using these techniques, we will investigate the relationship between neural activity and excitatory/inhibitory synaptic inputs during a behavior.
本研究では、運動中のマウス大脳皮質で同一のニューロンからその活動とシナプス入力を記録する方法を開発した。運動実行時に単一細胞へのシナプス入力を記録する方法はこれまで、その技術的困難さからほとんど研究が行われてこなかった。そのため本研究で開発した技術によって、新規の神経活動安定化のメカニズムを明らかにできると期待される。また、運動実行にかかわる神経活動安定化のメカニズム解明を通して、例えば、脳損傷後のリハビリテーションなどの効率化へとつながる事が期待される。
All 2020 2019 2018 2017
All Journal Article (3 results) (of which Peer Reviewed: 3 results, Open Access: 3 results) Presentation (12 results) (of which Int'l Joint Research: 3 results, Invited: 1 results)
Current Opinion in Neurobiology
Volume: 64 Pages: 103-110
10.1016/j.conb.2020.02.013
Proceedings of the National Academy of Sciences
Volume: 116 Issue: 45 Pages: 22844-22850
10.1073/pnas.1903445116
Nature Communications
Volume: 印刷中
