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Elucidation of mechanism behind highly efficient energy transduction of F1-ATPase

Research Project

Project/Area Number 17K14373
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biological physics/Chemical physics/Soft matter physics
Research InstitutionTohoku University (2018-2019)
Chuo University (2017)

Principal Investigator

NAKAYAMA Yohei  東北大学, 工学研究科, 特任助教 (20757728)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Discontinued (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords分子モーター / 生体エネルギー変換 / 非平衡熱力学 / 非平衡統計力学 / 生物物理
Outline of Final Research Achievements

We established a way to investigate the energy transduction efficiency of molecular motors in single molecule experiments without measuring independently the free energy change associated with chemical reactions. We revealed that the free energy change may not be obtained only from single molecule experiments, since a theoretical assumption is not always valid in the experimental situations. Instead, we developed a framework where the energy transduction efficiency is evaluated from the dependence of the work done by molecular motors on the concentrations of molecules involved in the chemical reaction.

Academic Significance and Societal Importance of the Research Achievements

これまで、生体分子モーターのエネルギー変換効率は、「生体内のエネルギー通貨」と呼ばれる分子であるアデノシン三リン酸をエネルギー源とする場合のみしか調べることができなかったが、今回の成果によりそれ以外の分子をエネルギー源とするときも議論がおこなえるようになった。人工的に設計された分子モーターのエネルギー源の種類は多岐にわたっているため、今回の成果は、それらのエネルギー変換効率の測定に道筋がついたという意義がある。

Report

(3 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Research-status Report
  • Research Products

    (15 results)

All 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (13 results) (of which Int'l Joint Research: 6 results,  Invited: 1 results)

  • [Journal Article] Unattainability of Carnot efficiency in thermal motors: Coarse graining and entropy production of Feynman-Smoluchowski ratchets2018

    • Author(s)
      Yohei Nakayama, Kyogo Kawaguchi, and Naoko Nakagawa
    • Journal Title

      Physical Review E

      Volume: 98 Issue: 2 Pages: 022102-022102

    • DOI

      10.1103/physreve.98.022102

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Entropy anomaly and linear irreversible thermodynamics2018

    • Author(s)
      Kunimasa Miyazaki and Yohei Nakayama and Hiromichi Matsuyama
    • Journal Title

      Phys. Rev. E

      Volume: 98 Issue: 2 Pages: 022101-022101

    • DOI

      10.1103/physreve.98.022101

    • NAID

      130007735955

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] F1-ATPaseの自由エネルギー地形と反応速度係数の実験的決定2018

    • Author(s)
      中山 洋平, 田中 真奈, 宗行 英朗
    • Organizer
      日本物理学会2018年秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 異常エントロピー生成と線形非平衡熱力学2018

    • Author(s)
      宮崎州正, 中山洋平, 松山洋道
    • Organizer
      日本物理学会2018年秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 温度上昇がF1-ATPaseのエネルギー変換効率に与える影響2018

    • Author(s)
      岡庭有明, 中山洋平, 宗行英朗
    • Organizer
      日本物理学会2018年秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Thermodynamic Efficiency of F1-ATPase at High Temperature2018

    • Author(s)
      Tomoaki Okaniwa, Yohei Nakayama, Eiro Muneyuki
    • Organizer
      The 56th Annual Meeting of the BSJ
    • Related Report
      2018 Annual Research Report
  • [Presentation] Langevin description of rotational motion of F1-ATPase2018

    • Author(s)
      Naomichi Tobita, Eiro Muneyuki, Yohei Nakayama
    • Organizer
      International Conference on APEF 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Measurement of Thermodynamic Efficiency of F1-ATPase at High Temperature2018

    • Author(s)
      Tomoaki Okaniwa, Yohei Nakayama, Eiro Muneyuki
    • Organizer
      International Conference on APEF 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Unreliability of stochastic thermodynamics to quantify the energy balance of F1-ATPase2018

    • Author(s)
      Naomichi Tobita, Eiro Muneyuki, Yohei Nakayama
    • Organizer
      Sendai Workshop 2018, An Update on Molecular Motors: Open Challenges and New Perspectives
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] F1-ATPaseにゆらぎの熱力学を適用する上での困難2018

    • Author(s)
      飛田直通, 中山洋平, 宗行英朗
    • Organizer
      日本物理学会 第73回年次大会
    • Related Report
      2017 Research-status Report
  • [Presentation] F1-ATPaseのエネルギー変換効率と熱安定性2018

    • Author(s)
      岡庭有明、田中真奈、中山洋平、宗行英朗
    • Organizer
      日本物理学会 第73回年次大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Coupling of Mechanical Rotation and ATPase Reaction in the F1-ATPase2017

    • Author(s)
      H. Narita, H, Hoshina, Y. Nakayama, H. Ueno, E. Muneyuki
    • Organizer
      「ゆらぎと構造の協奏」第4回領域研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Elucidation of the Timing of Phosphate Release during the Rotation of Thermophilic F1-ATPase2017

    • Author(s)
      H. Narita, H, Hoshina, Y. Nakayama, H. Ueno, E. Muneyuki
    • Organizer
      SFS2017: International Symposium on Fluctuation and Structure out of Equilibrium 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Maximum Likelihood Estimation of Stochastic Model of F1-ATPase2017

    • Author(s)
      Y. Nakayama, M. Tanaka, E. Muneyuki
    • Organizer
      SFS2017: International Symposium on Fluctuation and Structure out of Equilibrium 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Heat Dissipation from Rotating F1 Motor2017

    • Author(s)
      N. Tobita, Y. Nakayama, E. Muneyuki
    • Organizer
      SFS2017: International Symposium on Fluctuation and Structure out of Equilibrium 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-02-19  

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