Elucidation of mechanism behind highly efficient energy transduction of F1-ATPase
Project/Area Number |
17K14373
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Biological physics/Chemical physics/Soft matter physics
|
Research Institution | Tohoku University (2018-2019) Chuo University (2017) |
Principal Investigator |
NAKAYAMA Yohei 東北大学, 工学研究科, 特任助教 (20757728)
|
Project Period (FY) |
2017-04-01 – 2020-03-31
|
Project Status |
Discontinued (Fiscal Year 2019)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 分子モーター / 生体エネルギー変換 / 非平衡熱力学 / 非平衡統計力学 / 生物物理 |
Outline of Final Research Achievements |
We established a way to investigate the energy transduction efficiency of molecular motors in single molecule experiments without measuring independently the free energy change associated with chemical reactions. We revealed that the free energy change may not be obtained only from single molecule experiments, since a theoretical assumption is not always valid in the experimental situations. Instead, we developed a framework where the energy transduction efficiency is evaluated from the dependence of the work done by molecular motors on the concentrations of molecules involved in the chemical reaction.
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Academic Significance and Societal Importance of the Research Achievements |
これまで、生体分子モーターのエネルギー変換効率は、「生体内のエネルギー通貨」と呼ばれる分子であるアデノシン三リン酸をエネルギー源とする場合のみしか調べることができなかったが、今回の成果によりそれ以外の分子をエネルギー源とするときも議論がおこなえるようになった。人工的に設計された分子モーターのエネルギー源の種類は多岐にわたっているため、今回の成果は、それらのエネルギー変換効率の測定に道筋がついたという意義がある。
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Report
(3 results)
Research Products
(15 results)