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Study on chemical evolution using gas-phase clusters

Research Project

Project/Area Number 17K14441
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Physical chemistry
Research InstitutionOsaka Prefecture University

Principal Investigator

Fujihara Akimasa  大阪府立大学, 理学(系)研究科(研究院), 准教授 (10580334)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords化学進化 / 分子雲 / 分子認識 / キラル認識 / 定量分析 / エナンチオマー / 構造異性体 / 不斉反応 / ホモキラリティー
Outline of Final Research Achievements

Chiral recognition between amino acids and carbohydrates in cold gas-phase cluster ions was investigated as a model for chemical evolution in interstellar molecular clouds using a tandem mass spectrometer containing a cold ion trap. The enantiomer selectivity in cold gas-phase clusters indicated that chirality of a molecule induced enantiomeric excess of other molecules via enantiomer-selective reactions in molecular clouds. Based on our results, the enantiomer- and isomer-selective phenomena we observed in the gas phase were applied for distinguishing and quantifying amino acids and carbohydrates in solution.

Academic Significance and Societal Importance of the Research Achievements

本研究での化学進化に関わるキラル認識と化学反応は、遷移金属を使わない不斉化学反応である。本研究は、有機化学分野で近年急速に開発が進められている有機分子触媒の基礎的知見となり、グリーンケミストリーを発展させる研究成果となる。質量分析感度で鏡像異性体を識別する本計測法と、化学進化の歴史に関する本研究成果は、分子の個性を活かした高感度定量分析法を開拓する基盤となる。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (14 results)

All 2019 2018 2017

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results) Presentation (6 results) (of which Invited: 1 results)

  • [Journal Article] Gas-phase N2 adsorption on mass-selected hydrogen-bonded cluster ions2019

    • Author(s)
      A. Fujihara, A. Shimada
    • Journal Title

      Chemical Physics Letters

      Volume: 718 Pages: 1-6

    • DOI

      10.1016/j.cplett.2019.01.029

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Determination of enantiomeric excess of amino acids using photodissociation of cold gas-phase Na+-containing clusters2019

    • Author(s)
      D.T. Nguyen, N. Oki, A. Fujihara
    • Journal Title

      Journal of Mass Spectrometry

      Volume: 54 Issue: 7 Pages: 0-0

    • DOI

      10.1002/jms.4373

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular recognition and quantitative analysis of leucine and isoleucine using photodissociation of cold gas-phase noncovalent complexes2018

    • Author(s)
      N. Oki, A. Fujihara
    • Journal Title

      Journal of Mass Spectrometry

      Volume: 53 Issue: 7 Pages: 595-597

    • DOI

      10.1002/jms.4196

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chiral and molecular recognition of monosaccharides by photoexcited tryptophan in cold gas-phase noncovalent complexes as a model for chemical evolution in interstellar molecular clouds2018

    • Author(s)
      A. Fujihara, Y. Okawa
    • Journal Title

      Analytical and Bioanalytical Chemistry

      Volume: 410 Issue: 24 Pages: 6279-6287

    • DOI

      10.1007/s00216-018-1238-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chiral recognition in cold gas-phase cluster ions of carbohydrates and tryptophan probed by photodissociation2018

    • Author(s)
      D.T. Nguyen, A. Fujihara
    • Journal Title

      Origins of Life and Evolution of Biospheres

      Volume: 48 Issue: 4 Pages: 395-406

    • DOI

      10.1007/s11084-019-09574-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enantiomer-selective photo-induced reaction of protonated tryptophan with disaccharides in the gas phase2018

    • Author(s)
      T. N. Doan, A. Fujihara
    • Journal Title

      Origins of Life and Evolution of Biospheres

      Volume: 48 Issue: 1 Pages: 123-130

    • DOI

      10.1007/s11084-017-9544-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chiral and molecular recognition through protonation between aromatic amino acids and tripeptides probed by collision-activated dissociation in the gas phase2018

    • Author(s)
      A. Fujihara, H. Inoue, M. Sogi, M. Tajiri, Y. Wada
    • Journal Title

      Molecules

      Volume: 23 Issue: 1 Pages: 162-172

    • DOI

      10.3390/molecules23010162

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative chiral analysis of amino acids in solution using enantiomer-selective photodissociation of cold gas-phase tryptophan via chiral recognition2017

    • Author(s)
      A. Fujihara, N. Maeda
    • Journal Title

      Analytica Chimica Acta

      Volume: 979 Pages: 31-35

    • DOI

      10.1016/j.aca.2017.04.027

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 模擬分子雲におけるキラル認識と化学進化の研究に向けて2019

    • Author(s)
      藤原 亮正
    • Organizer
      第8回イオン移動度研究会/第72回イオン反応研究会 合同講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 低温孤立状態におけるトリプトファンと糖のキラル認識と光化学反応2017

    • Author(s)
      NGUYEN DOAN THUC・藤原亮正
    • Organizer
      第6回イオン移動度研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Enantiomer-selective photo-induced chemical reaction between disaccharides and protonated tryptophan in the gas phase2017

    • Author(s)
      Thuc NGUYEN DOAN, Akimasa FUJIHARA
    • Organizer
      International Symposium on "Diversity of Chemical Reaction Dynamics"
    • Related Report
      2017 Research-status Report
  • [Presentation] Chiral recognition and enantiomer-selective dissociation of amino acids in cold gas-phase clusters as a model of interstellar molecular clouds2017

    • Author(s)
      Akimasa FUJIHARA
    • Organizer
      International Symposium on "Diversity of Chemical Reaction Dynamics"
    • Related Report
      2017 Research-status Report
  • [Presentation] 模擬星間分子雲でのアミノ酸のキラル認識とエナンチオマー選択的光解離2017

    • Author(s)
      藤原亮正
    • Organizer
      新アミノ酸分析研究会第7回学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] プロトン付加で芳香族アミノ酸をキラル認識するトリペプチドのアミノ酸配列決定2017

    • Author(s)
      井上光・藤原亮正・田尻道子・和田芳直
    • Organizer
      新アミノ酸分析研究会第7回学術講演会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2020-03-30  

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