| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Actin is ubiquitous cytoskeletal protein, forming a dynamic network that generates mechanical force in the cells. In order to dissect the complex mechanism of actin-related cellular functions, we have succeeded in developing tools for actin manipulation in living cells by utilizing a newly discovered actin-binding small molecule. The manipulation tools enables highly specific green-light-controlled fragmentation of actin filament, affording unprecedented control of the actin cytoskeleton and its force network in living cells.
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