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Red Blood Cells Behavior "Chameleon Effect"

Research Project

Project/Area Number 17K14625
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionOsaka University

Principal Investigator

Mitsuhiro Horade  大阪大学, 工学研究科, 助教 (30583116)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords細胞操作 / 細胞特性計測 / ナノ・マイクロシステム / 知能機械学 / 画像解析 / 細胞特性計億 / 画像処理
Outline of Final Research Achievements

When constraining red blood cells in a microchannel simulating a blood capillary and loading time was increased, there was a phenomenon in which the color of red blood cells changed dramatically. This phenomenon was named "chameleon effect", and tried to clarify why color change occurs by spatio-temporal analysis of red blood cell behavior (color and shape) with high precision based on visualization method by vision. As a result, it was suggested that physical load might be the cause when investigating the area where color change occurs and the time region.There have been no research reports using color as an indicator for analyzing behavior change of red blood cells, but from this research result, it can be expected to lead to diagnostic application using color change as an indicator.

Academic Significance and Societal Importance of the Research Achievements

拘束中の赤血球は色変化と合わせて形状変化も起こしていることが確認できた.赤血球変形性能は循環器系疾患と密接な関係があるため,色変化を評価指標にした医療応用への可能性が期待できる.特に顕微鏡下で挙動をその場で確認できるため,診断応用においても早期発見等に繋がる可能性もあり,これまで実施例のなかった色を指標にした学術的研究を実施できたことは,診断応用や診断装置開発において新たな知見となった.

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (8 results)

All 2019 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] On-Chip Cell Incubator for Simultaneous Observation of Culture with and without Periodic Hydrostatic Pressure2019

    • Author(s)
      Horade Mitsuhiro、Tsai Chia-Hung、Kaneko Makoto
    • Journal Title

      Micromachines

      Volume: 10 Issue: 2 Pages: 133-133

    • DOI

      10.3390/mi10020133

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Development of micromanipulator with semiconductor strain gauge that can be used in solution2018

    • Author(s)
      Mitsuhiro Horade
    • Organizer
      Micro Alliance
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ナノ凹凸表面を利用した新規細胞パターニング方法の確立2018

    • Author(s)
      洞出光洋
    • Organizer
      第35回「センサ・マイクロマシンと応用システム」
    • Related Report
      2018 Annual Research Report
  • [Presentation] 微細加工技術を用いたライフサイエンス分野への応用研究2018

    • Author(s)
      洞出光洋
    • Organizer
      第4回バイオナノミクス基盤技術研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 細胞硬さ計測のための半導体ひずみゲージの開発2018

    • Author(s)
      洞出光洋
    • Organizer
      微細加工とその応用シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 赤血球”カメレオン効果”(ポスター)2017

    • Author(s)
      洞出光洋,蔡佳宏,伊藤弘明,金子真
    • Organizer
      ロボティクス・メカトロニクス 講演会- 2017
    • Related Report
      2017 Research-status Report
  • [Presentation] On-chip Cell Gymの設計と動作確認実験(ポスター)2017

    • Author(s)
      洞出 光洋, 伊藤 弘明, 蔡 佳宏, 高山 俊男, 金子 真
    • Organizer
      第34回「センサ・マイクロマシンと応用システム」
    • Related Report
      2017 Research-status Report
  • [Presentation] 半導体ひずみゲージ集積型マイクロツールの設計(ポスター)2017

    • Author(s)
      洞出光洋、田畑修、伊藤弘明、高山俊男、新井健生、金子真
    • Organizer
      第18回 計測自動制御学会システムインテグレーション部門講演会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2020-03-30  

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