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Formation of Higher Order Structure by Printing Method and Its Application to Wearable Biosignal Measuring Devices

Research Project

Project/Area Number 17K14823
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Composite materials/Surface and interface engineering
Research InstitutionOsaka University

Principal Investigator

Noda Yuki  大阪大学, 産業科学研究所, 特任助教(常勤) (30784748)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords生体信号 / 脳波 / ノイズ / S/N比 / ゲル / メゾクスコピック構造 / 金ナノワイヤ / インピーダンス / SN比 / 粘着剤 / 印刷形成 / 生体材料 / ハイブリッド / 先端機能デバイス / フレキシブル / 印刷技術
Outline of Final Research Achievements

In this research, we developed a conductive adhesive to obtain weak biological signals with a high signal-to-noise ratio. The noise reduction effect was demonstrated by measuring brain waves. The conductive adhesive is composed of biocompatible alpha-glucose and boric acid. The alpha-glucose chain was cross-linked by boric acid, resulting in improved strength and adhesion of the adhesive.The contact resistance to the skin and the noise power spectra of the EEG were analyzed. As a result, it was found that the developed gel has the ability to reduce the intensity of humming noise, a type of external noise, to a level comparable to the conductive pastes used in the medical field.

Academic Significance and Societal Importance of the Research Achievements

アルツハイマーやてんかんに代表される脳の異常を早期に察知することは、今後の少子高齢化社会において各人が健康的に過ごす為には必要不可欠である。脳波や心電のような生体信号は1000Hz以下の低周波帯域に観測される信号であり、そのオーダーはミリからマイクロボルトと微弱である。そのような微弱信号を日常的に計測するためには、計測機器の小型化は当然の事ながら、皮膚に直接接触する電極材料の安全性や使い勝手、高いセンサ性能が求められる。本研究は従来脳波計測で用いられてきた使い勝手の悪いペースト状の導電性材料を、優れた特性を保ったまま使い易いゲル状の材料に置き換える方針を提示する。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (10 results)

All 2019 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Flexible electronics for bio-signal monitoring in implantable applications2017

    • Author(s)
      Shusuke Yoshimoto, Teppei Araki, Takafumi Uemura, Yuki Noda, and Tsuyoshi Sekitani
    • Journal Title

      IEICE Electronics Express

      Volume: 14 Issue: 20 Pages: 20172003-20172003

    • DOI

      10.1587/elex.14.20172003

    • NAID

      130006179855

    • ISSN
      1349-2543
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Flexible Sensor Sheet for Real-Time Pressure Monitoring in Artificial Knee Joint During Total Knee Arthroplasty2017

    • Author(s)
      Fumika Tanabe, Shusuke Yoshimoto, Yuki Noda, Teppei Araki, Takafumi Uemura, Yoshinori Takeguchi, Masaharu Imai, and Tsuyoshi Sekitani
    • Journal Title

      the IEEE Engineering in Medicine and Biology Society

      Volume: - Pages: 1591-1594

    • DOI

      10.1109/embc.2017.8037142

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Development of Conductive Gel for Sensing EEG with High S/N Ratio2019

    • Author(s)
      Yuki Noda, Naomi Toyoshima, Makiko Kimura, Hirokazu Iida, Toshikazu Nezu, Teppei Araki, Shusuke Yoshimoto, Takafumi Uemura and Tsuyoshi Sekitani
    • Organizer
      International Congress on Advanced Materials Sciences and Engineering 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Biocompatible gel for EEG measurement with high S/N ratio2019

    • Author(s)
      Yuki Noda, Naomi Toyoshima, Makiko Kimura, Hirokazu Iida, Toshikazu Nezu, Teppei Araki, Shusuke Yoshimoto, Takafumi Uemura and Tsuyoshi Sekitani
    • Organizer
      MRM2019 G-1 Symposium: In-field Molecules for Next-generations Flexible Electronics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design of Conductive Gel for Sensing Weak Biosignals with High S/N Ratio2018

    • Author(s)
      Yuki Noda, Naomi Toyoshima, Teppei Araki, Shusuke Yoshimoto, Takafumi Uemura, and Tsuyoshi Sekitani
    • Organizer
      2018 Material Research Society (MRS) Fall meeting & exhibit
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of Biocompatible Gel for Measuring the Biosignal with Low Noise2018

    • Author(s)
      Yuki Noda, Naomi Toyoshima, Teppei Araki, Shusuke Yoshimoto, Iida Hirokazu, Takafumi Uemura, and Tsuyoshi Sekitani
    • Organizer
      67th Symposium on Macromolecules
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] A High-Resolution Printing Technique of Ag-Nanowire-Based Electrodes for Transparent Flexible Organic Transistors on a 1-μm-Thick Polymer Film2018

    • Author(s)
      Ashuya Takemoto, Teppei Araki, Yuki Noda, Shusuke Yoshimoto, Takafumi Uemura, and Tsuyoshi Sekitani
    • Organizer
      2018 Material Research Society (MRS) Spring meeting & exhibit, Symposium
    • Related Report
      2017 Research-status Report
  • [Presentation] Two-Months-Implantable Neural Interface Integrated with Transparent and Stretchable Metal-Nanowire-Based Tracks2018

    • Author(s)
      Teppei Araki, Fumiaki Yoshida, Yuki Noda, Takafumi Uemura, Shusuke Yoshimoto, Taro Kaiju, Takafumi Suzuki, Hiroki Hamanaka, Masayuki Hirata, and Tsuyoshi Sekitani
    • Organizer
      2018 Material Research Society (MRS) Spring meeting & exhibit, Symposium
    • Related Report
      2017 Research-status Report
  • [Patent(Industrial Property Rights)] 電極構造体、粘着剤形成用組成物、多糖の架橋物、及び 粘着剤形成用組成物の製造方法2019

    • Inventor(s)
      野田祐樹 関谷毅 豊嶋尚美
    • Industrial Property Rights Holder
      野田祐樹 関谷毅 豊嶋尚美
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 電極構造体、粘着剤形成用組成物、多糖の架橋物、及び 粘着剤形成用組成物の製造方法2019

    • Inventor(s)
      野田祐樹
    • Industrial Property Rights Holder
      豊嶋尚美 関谷毅
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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