Elucidating neural activity to improve treatment of anxiety disorders.
| Project/Area Number |
17K14926
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 神経科学 / 不安障害 / 記憶学習 / 光遺伝学 / 記憶・学習 / カルシウムイメージング |
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| Outline of Final Research Achievements |
The purpose of this study is to elucidate the neural mechanism to overcome fear to achieve goals. Using immunostaining for cFos, a neural activity marker, we comprehensively examined brain regions that were activated when mice overcome fear. Based on this result, we focused on the medial prefrontal cortex (mPFC) and found that pharmacological inhibition of the mPFC facilitated to overcome fear. Patients with anxiety disorders feel excessive fear and that makes it difficult for them to take appropriate action. The present study revealed that mPFC is involved in overcoming fear and taking action in a conflict environment. These results will contribute to elucidating the mechanism by which animals flexibly adjust their behavior in response to the external environment and their own circumstances, and to proposing science-based methods for treating anxiety disorders.
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| Academic Significance and Societal Importance of the Research Achievements |
不安障害を患うと、本来恐怖の対象とするべき事物や出来事以外に対しても恐怖を感じ、適切な行動を取ることが困難になり、患者のQOLを著しく低下させてしまう。本研究は、葛藤環境で恐怖を克服して行動を起こすことに mPFC が関与することを明らかにした。本成果は、生物が外界の環境や自身の状況に応じて行動を柔軟に調節するメカニズムを解明し、科学的根拠に基づいた不安障害の治療法や治療を効率化する方法を提案することに貢献すると考えられる。
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Report
(5 results)
Research Products
(6 results)
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[Presentation] Top-down control of mouse exploratory behaviors2018
Author(s)
Natsuko Hitora-Imamura , Ryoki Saito, Hikaru Igarashi, Daiki Takahashi, Yuji Ikegaya, Masabumi Minami, Hiroshi Nomura
Organizer
GRC, Optogenetics and Imaging: Technology Development, Novel Applications, and Closing the Loop Between Models and Experiments
Related Report
Int'l Joint Research
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