Information transmission from the claustrum to the entorhinal cortex
| Project/Area Number |
17K14939
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 前障 / 嗅内野 / 空間記憶 / 細胞外計測 / 光遺伝学 / 格子細胞 / 頭方向細胞 / 海馬 / 大規模細胞外計測 / 神経情報処理 / 大規模活動計測 |
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| Outline of Final Research Achievements |
The claustrum is a deep brain region whose function remains unknown. Recently, we found that the claustrum densely projects to the medial entorhinal cortex (MEC) and regulates contextual memory. In this study, we aimed to clarify the information transmission from the claustrum to the MEC. We established an optogenetic-electrophysiological system to monitor MEC activity in freely behaving animals while manipulating MEC-projecting claustral neurons with optogenetics. The data suggested that, irrespective of the optogenetic activation, grid cells and head direction cells in the superficial layer of MEC maintain a stable firing pattern.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで前障の機能解明が進んでいない理由として、前障は細長い形状をした脳領域であり、選択的な操作が難しかった点が挙げられる。本研究は、前障から特定の領域 (嗅内野) へと投射する神経細胞を選択的に標識・光操作しつつ、さらに自由行動中の神経活動を計測する実験系を確立した。これは、前障の機能解明のために重要なステップであり、当該分野において意義深いと考える。前障が嗅内野の活動にどのように影響を与えるのか、その全容解明のために更なる研究が必要である。
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Report
(4 results)
Research Products
(24 results)
