| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The claustrum is a deep brain region whose function remains unknown. Recently, we found that the claustrum densely projects to the medial entorhinal cortex (MEC) and regulates contextual memory. In this study, we aimed to clarify the information transmission from the claustrum to the MEC. We established an optogenetic-electrophysiological system to monitor MEC activity in freely behaving animals while manipulating MEC-projecting claustral neurons with optogenetics. The data suggested that, irrespective of the optogenetic activation, grid cells and head direction cells in the superficial layer of MEC maintain a stable firing pattern.
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