| Project/Area Number |
17K14944
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Research Collaborator |
LEIWE Marcus
AIHARA Shuhei
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 自発神経活動 / 神経回路形成 / 樹状突起 / 嗅球 / 僧帽細胞 / 神経科学 |
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| Outline of Final Research Achievements |
In the mouse olfactory bulb, each mitral cell extends a single primary dendrite toward the single glomerulus and receives olfactory receptor-specific inputs from olfactory sensory neurons (OSNs). This specific circuitry is the basis for odor discrimination. However, it remained unclear that how this discrete connection is established during development. In this study, we revealed that spontaneous network activity that is generated by glutamatergic synaptic transmission among mitral/tufted cells but not from OSNs is essential for dendrite pruning mediated circuit formation.
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| Academic Significance and Societal Importance of the Research Achievements |
発達期における感覚入力に依存しない内在性の自発神経活動は嗅球だけではなく多くの脳領域で観察されているが、未だにその意義や役割については不明な点が多い。本研究により神経回路の接続特異性決定の一端を担う役割が明らかになったとともに、脳の自己組織化における自発神経活動の重要性を示唆する結果が得られたと考える。
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