Neural circuits controlling habitual decision making: Elucidation of the brain network originating from the corticostriatal pathway

• Project/Area Number: 17K14951
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Niigata University
• Principal Investigator: Yoshioka Nozomu 新潟大学, 研究推進機構, 助教 (20708375)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 大脳基底核 / 皮質線条体路 / ウイルスベクター / 光遺伝学 / 化学遺伝学 / 細胞標的法 / マウス遺伝学 / 道具的条件づけ / 意思決定 / 習慣化 / イムノトキシン / 道具的条件付け / 神経回路操作

Outline of Final Research Achievements

Animals are able to switch from goal directed decision-making to habitual decision-making through a repeated learning. The goal directed decision-making is flexible action, and habitudal decision-making is automatic action. The role of the corticostriatal pathway in goal directed decision-making has been reported, but the involvement of the corticostriatal pathway in habitual decision-making is largely unknown. In this study, we focused on the corticostriatal pathway as a neural circuit that controls habitual decision making, and evaluated roles of this pathyway by using a neural pathway-selective gene expression system.

Academic Significance and Societal Importance of the Research Achievements

本研究課題では、ウイルスベクターを用いた神経回路選択的な遺伝子発現システムを構築した。本課題では、行動の習慣化に関わる神経回路として皮質線条体路に着目して、その機能を行動生理学、電気生理学、神経解剖学によって解析した。行動の習慣化は、様々な行動学習の根幹に関わる現象であり、強迫性障害や薬物依存症などの精神疾患の病態機序の理解にも繋がる成果が期待される。

Research Products

• [Int'l Joint Research] ジャクソン研究所(米国)
• [Journal Article] Retrograde gene transfer into neural pathways mediated by adeno-associated virus (AAV)-AAV receptor interaction (2020)
  • Author(s): Sano H, Kobayashi K, Yoshioka N, Takebayashi H, Nambu A.
  • Journal Title: J Neurosci Methods Volume: 345 Pages: 108887-108887
  • DOI: 10.1016/j.jneumeth.2020.108887
  • Peer Reviewed
• [Journal Article] Diverse dystonin gene mutations cause distinct patterns of Dst isoform deficiency and phenotypic heterogeneity in dystonia musculorum mice. (2020)
  • Author(s): Yoshioka N, Kabata Y, Kuriyama M, Bizen N, Zhou L, Tran DM, Yano M, Yoshiki A, Ushiki T, Sproule TJ, Abe R, and Takebayashi H
  • Journal Title: Dis Model Mech Volume: 印刷中
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Disruption of dystonin in Schwann cells results in late-onset neuropathy and sensory ataxia. (2020)
  • Author(s): Horie M, Yoshioka N, Kusumi S, Sano H, Kurose M, Watanabe-Iida I, Hossain MI, Chiken S, Abe M, Yamamura K, Sakimura K, Nambu A, Shibata M, Takebayashi H
  • Journal Title: Glia Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Action Selection and Flexible Switching Controlled by the Intralaminar Thalamic Neurons (2018)
  • Author(s): Kato Shigeki、Fukabori Ryoji、Nishizawa Kayo、Okada Kana、Yoshioka Nozomu、Sugawara Masateru、Maejima Yuko、Shimomura Kenju、Okamoto Masahiro、Eifuku Satoshi、Kobayashi Kazuto
  • Journal Title: Cell Reports Volume: 22 Issue: 9 Pages: 2370-2382
  • DOI: 10.1016/j.celrep.2018.02.016
  • Peer Reviewed / Open Access
• [Journal Article] BPAG1 in muscles: Structure and function in skeletal, cardiac and smooth muscle (2017)
  • Author(s): Masao Horie, Nozomu Yoshioka, Hirohide Takebayashi
  • Journal Title: Seminars in Cell and Developmental Biology Volume: 69 Pages: 26-33
  • DOI: 10.1016/j.semcdb.2017.07.016
  • Peer Reviewed
• [Journal Article] Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex (2017)
  • Author(s): Hou X, Yoshioka N, Tsukano H, Sakai A, Miyata S, Watanabe Y, Yanagawa Y, Sakimura K, Takeuchi K, Kitagawa H, Hensch TK, Shibuki K, Igarashi M, Sugiyama S
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 12646-12646
  • DOI: 10.1038/s41598-017-04007-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis (2017)
  • Author(s): Yoshioka Nozomu、Miyata Shinji、Tamada Atsushi、Watanabe Yumi、Kawasaki Asami、Kitagawa Hiroshi、Takao Keizo、Miyakawa Tsuyoshi、Takeuchi Kosei、Igarashi Michihiro
  • Journal Title: Mol Brain Volume: 10 Issue: 1 Pages: 47-47
  • DOI: 10.1186/s13041-017-0328-5
  • Peer Reviewed / Open Access
• [Journal Article] Motoneuron degeneration in the trigeminal motor nucleus innervating the masseter muscle in Dystonia musculorum mice (2017)
  • Author(s): Hossain M. Ibrahim、Horie Masao、Yoshioka Nozomu、Kurose Masayuki、Yamamura Kensuke、Takebayashi Hirohide
  • Journal Title: Neurochem Int Volume: - Pages: 159-170
  • DOI: 10.1016/j.neuint.2017.10.009
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Distinct dystonin gene mutations differently affect epidermal Dst-e isoform and hemidesmosomes (2021)
  • Author(s): Yoshioka N, Kabata Y, Kuriyama M, Bizen N, Zhou L, Tran DM, Yano M, Yoshiki A, Ushiki T, Sproule TJ, Abe R, and Takebayashi H
  • Organizer: 第126回日本解剖学会総会・全国学術集会
• [Presentation] Diverse dystonin gene mutations cause distinct patterns of Dst isoform deficiency and phenotypic heterogeneity (2020)
  • Author(s): Yoshioka N, Kabata Y, Kuriyama M, Bizen N, Zhou L, Tran DM, Yano M, Yoshiki A, Ushiki T, Sproule TJ, Abe R, and Takebayashi H
  • Organizer: Forum of European Neuroscience Virtual Forum
  • Int'l Joint Research
• [Presentation] dystonia musculorumマウスの運動異常に関する神経回路基盤の解析 (2020)
  • Author(s): 吉岡 望、竹林 浩秀
  • Organizer: 第125回 日本解剖学会総会
• [Presentation] Neural circuit mechanisms underlying dystonia-like movement disorder in dystonia musculorum mice (2019)
  • Author(s): Yoshioka N, Kurose M, Yamamura K, Takebayashi H
  • Organizer: Neuro2019 サテライトシンポジウム「大脳基底核の機能と疾患の新たな理解：基礎と臨床」
  • Invited
• [Presentation] Conditional rescue of dystonin in peripheral nervous system in mouse model of hereditary sensory autonomic neuropathy VI (2019)
  • Author(s): 吉岡 望、竹林 浩秀
  • Organizer: 第42回 日本神経科学大会
• [Presentation] 末梢神経系におけるdystonin遺伝子トラップによる遺伝性感覚性自律神経性ニューロパチー6型の新規モデル動物の確立 (2019)
  • Author(s): 吉岡 望、竹林 浩秀
  • Organizer: 124回日本解剖学会総会
• [Presentation] 末梢神経系におけるDystonin cKOマウス作製による遺伝性感覚性自律神経性ニューロパチーVI型の新規モデル動物の確立 (2018)
  • Author(s): 吉岡 望、竹林 浩秀
  • Organizer: 第41回 日本神経科学会
• [Presentation] 髄鞘形成不全マウス白質におけるミクログリア活性増強の免疫組織化学的解析 (2018)
  • Author(s): 五十嵐 恵介、目黒 玲子、竹林 浩秀、吉岡 望
  • Organizer: 第41回 日本神経科学会
• [Presentation] 運動異常を示すdystonia musculorumマウスの神経回路基盤の解析―遺伝子トラップマウスを用いた選択的遺伝子改変法によるアプローチ― (2018)
  • Author(s): 吉岡 望
  • Organizer: 次世代脳冬のシンポジウム
• [Presentation] コンドロイチン硫酸合成酵素欠損マウスにおけるペリニューロナルネットの糖鎖異常 (2018)
  • Author(s): 吉岡 望
  • Organizer: 先端モデル動物支援プラットフォーム 成果発表会
• [Presentation] 末梢神経系特異的なDystonin KOマウスを用いた遺伝性ニューロパチーの病態解析 (2018)
  • Author(s): 吉岡 望
  • Organizer: 第123回日本解剖学会
• [Presentation] 神経回路選択的な遺伝子発現系による皮質線条体路の解析 (2017)
  • Author(s): 吉岡 望
  • Organizer: 第60回日本神経化学会
• [Presentation] 運動・認知機能における錐体外路の機能解析 (2017)
  • Author(s): 吉岡 望
  • Organizer: 2017年度包括脳冬のシンポジウム
• [Remarks]
  • URL: https://www.irp.niigata-u.ac.jp/business/tenure-track/tt-researcher/yoshioka-nozomu/