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Neural circuits controlling habitual decision making: Elucidation of the brain network originating from the corticostriatal pathway

Research Project

Project/Area Number 17K14951
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Nerve anatomy/Neuropathology
Research InstitutionNiigata University

Principal Investigator

Yoshioka Nozomu  新潟大学, 研究推進機構, 助教 (20708375)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords大脳基底核 / 皮質線条体路 / ウイルスベクター / 光遺伝学 / 化学遺伝学 / 細胞標的法 / マウス遺伝学 / 道具的条件づけ / 意思決定 / 習慣化 / イムノトキシン / 道具的条件付け / 神経回路操作
Outline of Final Research Achievements

Animals are able to switch from goal directed decision-making to habitual decision-making through a repeated learning. The goal directed decision-making is flexible action, and habitudal decision-making is automatic action. The role of the corticostriatal pathway in goal directed decision-making has been reported, but the involvement of the corticostriatal pathway in habitual decision-making is largely unknown. In this study, we focused on the corticostriatal pathway as a neural circuit that controls habitual decision making, and evaluated roles of this pathyway by using a neural pathway-selective gene expression system.

Academic Significance and Societal Importance of the Research Achievements

本研究課題では、ウイルスベクターを用いた神経回路選択的な遺伝子発現システムを構築した。本課題では、行動の習慣化に関わる神経回路として皮質線条体路に着目して、その機能を行動生理学、電気生理学、神経解剖学によって解析した。行動の習慣化は、様々な行動学習の根幹に関わる現象であり、強迫性障害や薬物依存症などの精神疾患の病態機序の理解にも繋がる成果が期待される。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (23 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (8 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 8 results,  Open Access: 4 results) Presentation (13 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (1 results)

  • [Int'l Joint Research] ジャクソン研究所(米国)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Retrograde gene transfer into neural pathways mediated by adeno-associated virus (AAV)-AAV receptor interaction2020

    • Author(s)
      Sano H, Kobayashi K, Yoshioka N, Takebayashi H, Nambu A.
    • Journal Title

      J Neurosci Methods

      Volume: 345 Pages: 108887-108887

    • DOI

      10.1016/j.jneumeth.2020.108887

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diverse dystonin gene mutations cause distinct patterns of Dst isoform deficiency and phenotypic heterogeneity in dystonia musculorum mice.2020

    • Author(s)
      Yoshioka N, Kabata Y, Kuriyama M, Bizen N, Zhou L, Tran DM, Yano M, Yoshiki A, Ushiki T, Sproule TJ, Abe R, and Takebayashi H
    • Journal Title

      Dis Model Mech

      Volume: 印刷中

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Disruption of dystonin in Schwann cells results in late-onset neuropathy and sensory ataxia.2020

    • Author(s)
      Horie M, Yoshioka N, Kusumi S, Sano H, Kurose M, Watanabe-Iida I, Hossain MI, Chiken S, Abe M, Yamamura K, Sakimura K, Nambu A, Shibata M, Takebayashi H
    • Journal Title

      Glia

      Volume: 印刷中

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Action Selection and Flexible Switching Controlled by the Intralaminar Thalamic Neurons2018

    • Author(s)
      Kato Shigeki、Fukabori Ryoji、Nishizawa Kayo、Okada Kana、Yoshioka Nozomu、Sugawara Masateru、Maejima Yuko、Shimomura Kenju、Okamoto Masahiro、Eifuku Satoshi、Kobayashi Kazuto
    • Journal Title

      Cell Reports

      Volume: 22 Issue: 9 Pages: 2370-2382

    • DOI

      10.1016/j.celrep.2018.02.016

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] BPAG1 in muscles: Structure and function in skeletal, cardiac and smooth muscle2017

    • Author(s)
      Masao Horie, Nozomu Yoshioka, Hirohide Takebayashi
    • Journal Title

      Seminars in Cell and Developmental Biology

      Volume: 69 Pages: 26-33

    • DOI

      10.1016/j.semcdb.2017.07.016

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex2017

    • Author(s)
      Hou X, Yoshioka N, Tsukano H, Sakai A, Miyata S, Watanabe Y, Yanagawa Y, Sakimura K, Takeuchi K, Kitagawa H, Hensch TK, Shibuki K, Igarashi M, Sugiyama S
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 12646-12646

    • DOI

      10.1038/s41598-017-04007-x

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis2017

    • Author(s)
      Yoshioka Nozomu、Miyata Shinji、Tamada Atsushi、Watanabe Yumi、Kawasaki Asami、Kitagawa Hiroshi、Takao Keizo、Miyakawa Tsuyoshi、Takeuchi Kosei、Igarashi Michihiro
    • Journal Title

      Mol Brain

      Volume: 10 Issue: 1 Pages: 47-47

    • DOI

      10.1186/s13041-017-0328-5

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Motoneuron degeneration in the trigeminal motor nucleus innervating the masseter muscle in Dystonia musculorum mice2017

    • Author(s)
      Hossain M. Ibrahim、Horie Masao、Yoshioka Nozomu、Kurose Masayuki、Yamamura Kensuke、Takebayashi Hirohide
    • Journal Title

      Neurochem Int

      Volume: - Pages: 159-170

    • DOI

      10.1016/j.neuint.2017.10.009

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Distinct dystonin gene mutations differently affect epidermal Dst-e isoform and hemidesmosomes2021

    • Author(s)
      Yoshioka N, Kabata Y, Kuriyama M, Bizen N, Zhou L, Tran DM, Yano M, Yoshiki A, Ushiki T, Sproule TJ, Abe R, and Takebayashi H
    • Organizer
      第126回日本解剖学会総会・全国学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Diverse dystonin gene mutations cause distinct patterns of Dst isoform deficiency and phenotypic heterogeneity2020

    • Author(s)
      Yoshioka N, Kabata Y, Kuriyama M, Bizen N, Zhou L, Tran DM, Yano M, Yoshiki A, Ushiki T, Sproule TJ, Abe R, and Takebayashi H
    • Organizer
      Forum of European Neuroscience Virtual Forum
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] dystonia musculorumマウスの運動異常に関する神経回路基盤の解析2020

    • Author(s)
      吉岡 望、竹林 浩秀
    • Organizer
      第125回 日本解剖学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Neural circuit mechanisms underlying dystonia-like movement disorder in dystonia musculorum mice2019

    • Author(s)
      Yoshioka N, Kurose M, Yamamura K, Takebayashi H
    • Organizer
      Neuro2019 サテライトシンポジウム「大脳基底核の機能と疾患の新たな理解:基礎と臨床」
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Conditional rescue of dystonin in peripheral nervous system in mouse model of hereditary sensory autonomic neuropathy VI2019

    • Author(s)
      吉岡 望、竹林 浩秀
    • Organizer
      第42回 日本神経科学大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 末梢神経系におけるdystonin遺伝子トラップによる遺伝性感覚性自律神経性ニューロパチー6型の新規モデル動物の確立2019

    • Author(s)
      吉岡 望、竹林 浩秀
    • Organizer
      124回日本解剖学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 末梢神経系におけるDystonin cKOマウス作製による遺伝性感覚性自律神経性ニューロパチーVI型の新規モデル動物の確立2018

    • Author(s)
      吉岡 望、竹林 浩秀
    • Organizer
      第41回 日本神経科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 髄鞘形成不全マウス白質におけるミクログリア活性増強の免疫組織化学的解析2018

    • Author(s)
      五十嵐 恵介、目黒 玲子、竹林 浩秀、吉岡 望
    • Organizer
      第41回 日本神経科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 運動異常を示すdystonia musculorumマウスの神経回路基盤の解析―遺伝子トラップマウスを用いた選択的遺伝子改変法によるアプローチ―2018

    • Author(s)
      吉岡 望
    • Organizer
      次世代脳冬のシンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] コンドロイチン硫酸合成酵素欠損マウスにおけるペリニューロナルネットの糖鎖異常2018

    • Author(s)
      吉岡 望
    • Organizer
      先端モデル動物支援プラットフォーム 成果発表会
    • Related Report
      2017 Research-status Report
  • [Presentation] 末梢神経系特異的なDystonin KOマウスを用いた遺伝性ニューロパチーの病態解析2018

    • Author(s)
      吉岡 望
    • Organizer
      第123回日本解剖学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 神経回路選択的な遺伝子発現系による皮質線条体路の解析2017

    • Author(s)
      吉岡 望
    • Organizer
      第60回日本神経化学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 運動・認知機能における錐体外路の機能解析2017

    • Author(s)
      吉岡 望
    • Organizer
      2017年度包括脳冬のシンポジウム
    • Related Report
      2017 Research-status Report
  • [Remarks]

    • URL

      https://www.irp.niigata-u.ac.jp/business/tenure-track/tt-researcher/yoshioka-nozomu/

    • Related Report
      2019 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

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