| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
TDP-43 is thought to be one of the genes responsible for ALS, and it is a mutation in the TDP-43 gene. The characteristic pathology of TDP-43 is also found in patients with ALS who do not have TDP-43. This study focused on the transcriptional regulatory function of TDP-43 and analyzed its function. Our results show that the promoter activity of TDP-43 was detected experimentally for the first time upstream of the transcriptional start site of TDP-43.We also found that the promoter activity was ectopic to the original promoter. In addition, the TDP-43 splice variant does not affect the upstream promoter of TDP-43 and the different It was found to activate only the locative promoter. The results of the research period were presented at Neuro2019.
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