The elucidation of functional role of CTRP6 in the development of osteoarthritis
| Project/Area Number |
17K14978
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Laboratory animal science
|
|---|
| Research Institution | Kansai Medical University (2019)
St. Marianna University School of Medicine (2018)
Tokyo University of Science (2017) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2017-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 変形性関節症 / CTRP6 / CTRP3 / 軟骨細胞 / 補体 / 動物 / 生理学 |
|---|
| Outline of Final Research Achievements |
Osteoarthritis is one of bone metabolic diseases. Although CTRP6-deficient induces osteoarthritis phenotype, the pathogenic mechanism of that phenotype is unknown. The elucidation of functional role of CTRP6 in the development of osteoarthritis and generation of new therapeutic agents are research purpose of this study. The results of this study, CTRP6 showed dual therapeutic effects for osteoarthritis. CTRP6 as a complement regulator, inhibits excess complement activation, and as a chondrocyte proliferation factor, promotes chondrocyte proliferation via CTRP6 receptors. In addition, I identified chondrocyte proliferation factor, CTRP3 receptor. These results used be a generation of new therapeutics against bone metabolic diseases including osteoarthritis.
|
| Academic Significance and Societal Importance of the Research Achievements |
変形性関節症は加齢や肥満と密接な関わりがあるため、超高齢化社会・生活習慣病が深刻化する日本では対策が必要な疾患の１つである。その治療は対処療法が主であるが、再生医療技術を活用した治療法が注目される。本研究では新たな軟骨細胞増殖因子および受容体の同定に成功した。これらの成果から安価で安定的な軟骨細胞の調整法の確立が期待されることから、軟骨細胞移植による軟骨再生医療の開発に多大な貢献となる。
|
Report
(4 results)
Research Products
(45 results)
-
-
-
[Journal Article] Transplantation of Human iPS Cell-Derived Neural Cells with an Artificial Nerve Conduit Leads to Cellular Retention in the Transplanted Area and Improves Motor Function in a Mouse Spinal Cord Injury Model2019
Author(s)
Tomochika K, Arimitsu N, Murayama MA, Hirotsu C, Nagata K, Takai K, Shimizu J, Akazawa T, Torii Y, Umehara T, Iinuma M, Niki H, Suzuki N.
-
Journal Title
Journal of St. Marianna University
Volume: 10
Issue: 2
Pages: 27-37
DOI
NAID
ISSN
2185-1336, 2189-0277
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
[Journal Article] Propionate-producing bacteria in the intestine may associate with skewed responses of IL10-producing regulatory T cells in patients with relapsing polychondritis.2018
Author(s)
Shimizu J, Kubota T, Takada E, Takai K, Fujiwara N, Arimitsu N, Murayama MA, Ueda Y, Wakisaka S, Suzuki T, Suzuki N
-
Journal Title
PLoS One
Volume: 20
Issue: 9
Pages: e0203657-e0203657
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] IL-36α from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop.2018
Author(s)
Hashiguchi Y, Yabe R, Chung SH, Murayama MA, Yoshida K, Matsuo K, Kubo S, Saijo S, Nakamura Y, Matsue H, Iwakura Y.
-
Journal Title
J Immunol.
Volume: 201
Issue: 1
Pages: 167-182
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] IL-1R2 deficiency suppresses dextran sodium sulfate-induced colitis in mice via regulation of microbiota.2018
Author(s)
Yoshida, K., Murayama, M., Shimizu, K., Tang, C., Katagiri, N., Matsuo, K., Fukai F., and Iwakura, Y.
-
Journal Title
Biochem. Biophys. Res. Commun.
Volume: 496
Issue: 3
Pages: 934-940
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Presentation] インテグリン関連疾患治療薬開発に向けた薬剤スクリーニング法の開発.2019
Author(s)
Ikeda Y, Kondo N, Takeda H, Makita Y, Fukunishi Y, Ueda Y, Sato K, Murayama M, Ma B, Isaka Y, Kawai K, Mashimo T, Kamioka Y, Araki M, Omote M, Kinasi T.
Organizer
第10回スクリーニング学研究会
Related Report
-
-
[Presentation] 完全離断精髄損傷マウスモデルに対する神経再生誘導チューブ併用ヒトiPS細胞由来神経幹/前駆細胞移植の検討.2019
Author(s)
友近顕, 有光なぎさ, 廣津千恵子, 高井憲治, 村山正承, 赤澤努, 梅原亮, 飯沼雅央, 清水潤, 仁木久照, 鈴木登.
Organizer
第34回日本整形外科学会基礎学術集会.
Related Report
-
[Presentation] 生物に普遍的に存在する分泌型リボヌクレアーゼ遺伝子欠損マウスの表現型解析.2019
Author(s)
王辰, 角田茂, 小川哲弘, 岩本京夏, 餅井眞太郎, Desamero Mark Joseph, 藤井渉, チェンバーズ ジェームズ, 内田萌菜, 村山正承, 小 川修平, 米澤智洋, 中山裕之, 岩倉洋一郎, 久和茂.
Organizer
第84回日本インターフェロン・サイトカイン学会学術集会
Related Report
-
-
-
[Presentation] 普遍的リボヌクレアーゼのin vivo機能解析.2019
Author(s)
角田茂, 小川哲弘, 藤井渉, チェンバーズ ジェームズ, 王辰, 餅井眞太郎, Mark Joseph Desamero, 岩本京夏, 内田萌菜, 村山正承, 小 川修平, 米澤智洋, 中山祐之, 岩倉洋一郎, 久和茂.
Organizer
第9回オルソオルガノジェネシス検討会
Related Report
-
-
-
-
-
-
-
-
-
[Presentation] 普遍的分泌型非特異的リボヌクレアーゼ遺伝子欠損マウスが呈する免疫異常の解析2018
Author(s)
角田茂, 小川哲弘, 藤井渉, チェンバーズ ジェームズ, 岩本京夏, Desamero Mark Joseph M., 内田萌菜, 秋津葵, 村山正承, 小川修平, 米澤智洋, 中山裕之, 岩倉洋一郎, 久和茂
Organizer
第65回日本実験動物学会総会
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
