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Global analysis of long non-coding RNA during gliomagenesis

Research Project

Project/Area Number 17K14995
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor biology
Research InstitutionNagoya University

Principal Investigator

Katsushima Keisuke  名古屋大学, 医学系研究科, 助教 (00754053)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords長鎖非翻訳RNA / 腫瘍生物学
Outline of Final Research Achievements

Control of gene expression by long non-coding RNAs (long non-coding RNAs, lncRNAs) is related to various biological processes. In recent research, lncRNA has been shown to be involved in the development and progression of cancer. In this study, we analyzed the lncRNA expression during tumorigenesis using genetically modified mice that naturally generate glioblastoma. As a result, Lnc-1 and Lnc-2, whose expression was increased during tumorigenesis, were significantly enhanced in glioblastoma in comparison with normal brain tissue. Furthermore, in human glioblastoma cells, suppression of Lnc-1 and Lnc-2 expression has a growth inhibitory effect, suggesting that Lnc-1 and Lnc-2 are lncRNAs involved in glioblastoma formation and progression.

Academic Significance and Societal Importance of the Research Achievements

本研究では膠芽腫自然発生マウスモデル、ヒト膠芽腫細胞株を用いて腫瘍形成に重要な役割を果たす長鎖非翻訳RNA (long non-coding RNA, lncRNA)を複数同定した。本研究成果により得られた知見は、現在までに効果的な治療法が確立されていない膠芽腫に対する治療戦略を考案するうえで重要な学術的意義、社会的意義を有するものであると考える。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (14 results)

All 2019 2018 2017

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (5 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Journal Article] ZNF671 DNA methylation as a molecular predictor for the early recurrence of serous ovarian cancer2019

    • Author(s)
      Mase Shoko、Shinjo Keiko、Totani Haruhito、Katsushima Keisuke、Arakawa Atsushi、Takahashi Satoru、Lai Hung-Cheng、Lin Ru-Inn、Chan Michael W. Y.、Sugiura-Ogasawara Mayumi、Kondo Yutaka
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 3 Pages: 1105-1116

    • DOI

      10.1111/cas.13936

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay2019

    • Author(s)
      Murashima Akihiro、Shinjo Keiko、Katsushima Keisuke、Onuki Tetsuo、Kondoh Yasumitsu、Osada Hiroyuki、Kagaya Noritaka、Shin-ya Kazuo、Kimura Hiroshi、Yoshida Minoru、Murakami Shingo、Kondo Yutaka.
    • Journal Title

      The Journal of Biochemistry

      Volume: - Issue: 1 Pages: 1-10

    • DOI

      10.1093/jb/mvz007

    • NAID

      40021952184

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 長鎖非コードRNA をターゲットにした膠芽腫の治療2018

    • Author(s)
      鈴木美穂、勝島啓佑、近藤豊
    • Journal Title

      Medical Science Digest

      Volume: 5月号 Pages: 238-240

    • Related Report
      2018 Annual Research Report
  • [Journal Article] EZH2阻害剤の作動原理と開発現状2018

    • Author(s)
      勝島啓佑、鈴木美穂、近藤豊
    • Journal Title

      医学のあゆみ

      Volume: 266 Pages: 18932-18938

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 長鎖非翻訳RNAを標的とする革新的核酸治療薬の開発2018

    • Author(s)
      勝島啓佑、近藤豊
    • Journal Title

      「BIO Clinica」

      Volume: 1 Pages: 28-33

    • Related Report
      2017 Research-status Report
  • [Journal Article] Oncogenic effects of evolutionarily conserved noncoding RNA ECONEXIN on gliomagenesis2017

    • Author(s)
      Deguchi S、Katsushima K、Hatanaka A、Shinjo K、Ohka F、Wakabayashi T、Zong H、Natsume A、Kondo Y
    • Journal Title

      Oncogene

      Volume: 36 Issue: 32 Pages: 4629-4640

    • DOI

      10.1038/onc.2017.88

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long non-coding RNAs as an epigenetic regulator in human cancers2017

    • Author(s)
      Kondo Yutaka、Shinjo Keiko、Katsushima Keisuke
    • Journal Title

      Cancer Science

      Volume: 108 Issue: 10 Pages: 1927-1933

    • DOI

      10.1111/cas.13342

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 長鎖非翻訳RNAを標的としたがん治療薬の開発2017

    • Author(s)
      勝島啓佑、近藤豊
    • Journal Title

      「腫瘍内科」

      Volume: 19 Pages: 454-461

    • Related Report
      2017 Research-status Report
  • [Journal Article] がん幹細胞とエピゲノム制御2017

    • Author(s)
      田崎慶彦、勝島啓佑、近藤豊
    • Journal Title

      「がん転移学」

      Volume: 75 Pages: 137-143

    • Related Report
      2017 Research-status Report
  • [Presentation] Development of anticancer agents targeting long non-coding RNA2018

    • Author(s)
      Katsushima K, Natsume A, Ohka F, Deguchi, S, Shinjo K, Shibata T, Miyata K, Kataoka K, Kondo Y
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Development of nucleic acid therapeutics targeting long non-coding RNA TUG12018

    • Author(s)
      Katsushima K, Natsume A, Ohka F, Deguchi S, Shinjo K, Shibata S, Miyata K, Kataoka K, Kondo Y
    • Organizer
      Keystone Symposia meeting on: Noncoding RNAs: Form, Function, Physiology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Targeting the Notch-regulated non-coding RNA, TUG1, as an effective treatment in glioblastoma2017

    • Author(s)
      Katsushima K, Kondo Y
    • Organizer
      Gordon Research Conferences, Conference: Cancer Genetics & Epigenetics
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Targeting long non-coding RNA, TUG1, as an effective treatment in cancer2017

    • Author(s)
      勝島啓佑, 夏目敦至, 大岡史治, 出口彰一, 新城恵子,柴田龍弘, 宮田完二郎, 片岡一則, 近藤豊
    • Organizer
      第11回日本エピジェネィクス研究会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 長鎖非翻訳RNA TUG1を標的としたがん治療薬の開発2017

    • Author(s)
      勝島啓佑, 夏目敦至, 大岡史治, 出口彰一, 新城恵子,柴田龍弘, 宮田完二郎, 片岡一則, 近藤豊
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report
    • Invited

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Published: 2017-04-28   Modified: 2020-03-30  

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