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Identification of diagnostic biomarker for glioblasotma with innovative proteomics

Research Project

Project/Area Number 17K15012
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor diagnostics
Research InstitutionKurume University

Principal Investigator

Furuta Takuya  久留米大学, 医学部, 助教 (20646690)

Research Collaborator NAKADA Mitsutoshi  
OTSUKI Sumio  
KOMAKI Satoru  
Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords膠芽腫 / バイオマーカー / プロテオミクス
Outline of Final Research Achievements

Among the six biomarker candidates extracted the SWATH screening, we focused on leucine-rich alpha-2 glycoprotein 1 (LRG1). Immunohistochemical study showed that LRG1 was expressed in the cytoplasm of glioblastoma cells and its expression was significantly high in glioblastoma cases compared with other diffuse glioma cases. Interestingly, high LRG1 expression was found to be a good prognositc factor for glioblastoma. It is suggested that LRG1 is not only a promising diagnostic biomarker histopathologically but also a favorable prognostic factor in glioblastoma.

Academic Significance and Societal Importance of the Research Achievements

膠芽腫は経過で治療が必要な真の再発か治療が不要な見かけ上の再発を呈することがしばしばある。真の再発を見逃せば治療介入が遅れ予後が悪化することになる。偽の再発を真の再発と誤診すれば無用の手術など侵襲の高い治療が行われる。本研究で見出した診断マーカーはいずれも新規性が高いだけでなく、真の再発を鋭敏に検知し適切な医療の実施につながると考えられる。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (4 results)

All 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results)

  • [Journal Article] Identification of blood biomarkers in glioblastoma by SWATH mass spectrometry and quantitative targeted absolute proteomics.2018

    • Author(s)
      Miyauchi E, Furuta T, Ohtsuki S, Tachikawa M, Uchida Y, Sabit H, Obuchi Wm Baba T, Watanabe M, Terasaki T, Nakada M
    • Journal Title

      PLoS One

      Volume: 13 Issue: 3 Pages: e0193799-e0193799

    • DOI

      10.1371/journal.pone.0193799

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 膠芽腫バイオマーカーLeucine-rich a-2 glycoprotein 1の臨床病理学的検討2018

    • Author(s)
      古田拓也
    • Organizer
      第36回日本脳腫瘍学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 悪性神経膠腫におけるLeucine-rich a-2 glycoprotein 1の臨床病理学的役割2018

    • Author(s)
      古田拓也
    • Organizer
      第36回日本脳腫瘍病理学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] SWATHプロテオミクスによる膠芽腫バイオマーカー探索2017

    • Author(s)
      古田拓也、小牧哲、宮内英輔、内田康雄、立川正憲、寺崎哲也、中田光俊
    • Organizer
      第76回日本脳神経外科学会学術総会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2020-03-30  

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