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Interspecies comparative analyses of distinct carbohydrate-responsive systems among Drosophila species

Research Project

Project/Area Number 17K15039
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Genome biology
Research InstitutionKyoto University

Principal Investigator

Hattori Yukako  京都大学, 生命科学研究科, 助教 (50646768)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords栄養 / 適応 / 成長 / 代謝 / マルチオミクス / 全身性シグナリング / 栄養バランス / 種間比較オミクス / 種間比較オミックス
Outline of Final Research Achievements

During evolution, organisms have acquired variable feeding habits. Some species are nutritional generalists that adapt to various food resources, while others are specialists, feeding on specific resources. However, much remains to be discovered regarding how generalists adapt to diversified diets. We found that larvae of the generalists, D. melanogaster and D. simulans developed on three diets with different nutrient balances, whereas specialist D. sechellia and D. elegans could not develop on carbohydrate-rich diets. The generalist D. melanogaster downregulated the expression of diverse metabolic genes systemically by TGF-b/Activin signaling, maintained metabolic homeostasis and successfully adapted to the diets. In contrast, the specialist D. sechellia expressed those metabolic genes at higher levels and accumulated various metabolites on the carbohydrate-rich diet, culminating in reduced adaptation.

Academic Significance and Societal Importance of the Research Achievements

本研究では、遺伝的に近縁ながら食性の異なる広食性種と狭食性種の間で、炭水化物応答制御機構の働きや異なる栄養バランスへの適応能力が違うことを明らかにしました。私たちヒトにおいても、肥満や糖尿病などの罹りやすさが人種や個体間で異なることが知られています。また、本研究で用いたショウジョウバエとヒトとの間では、組織やホルモンなどの制御因子の多くが共通しています。今後、本研究での成果や種間比較解析のアプローチを応用することで、個体間、そしてショウジョウバエ以外の生物種間においても、栄養やその他の環境因子に対する適応や生体応答の違いを生み出すメカニズムの研究が広く進むことが期待されます。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (37 results)

All 2020 2019 2018 2017 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (32 results) (of which Int'l Joint Research: 18 results,  Invited: 5 results) Remarks (2 results)

  • [Journal Article] 種間の栄養環境への適応能力の差を生む炭水化物応答機構2020

    • Author(s)
      渡辺佳織,上村 匡,服部佑佳子
    • Journal Title

      実験医学

      Volume: 38 Pages: 471-474

    • Related Report
      2019 Annual Research Report
  • [Journal Article] DeTerm: Software for automatic detection of neuronal dendritic branch terminals via an artificial neural network.2019

    • Author(s)
      Yasutetsu Kanaoka†, Henrik Skibbe†, Yusaku Hayashi, *Tadashi Uemura and *Yukako Hattori
    • Journal Title

      Genes Cells

      Volume: Jul;24(7) Issue: 7 Pages: 464-472

    • DOI

      10.1111/gtc.12700

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interspecies Comparative Analyses Reveal Distinct Carbohydrate-Responsive Systems among Drosophila Species.2019

    • Author(s)
      Kaori Watanabe, Yasutetsu Kanaoka, Shoko Mizutani, Hironobu Uchiyama, Shunsuke Yajima, Masayoshi Watada, Tadashi Uemura, Yukako Hattori
    • Journal Title

      Cell Reports

      Volume: 28(10) Issue: 10 Pages: 2594-2607

    • DOI

      10.1016/j.celrep.2019.08.030

    • NAID

      120006716587

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] The nutritional basis of Drosophila associated yeasts and bacteria for larval growth2020

    • Author(s)
      Ayumi Mure, Yuuki Takahashi, Masayoshi Watada, Toshihiko Katoh, Aina Gotoh, Takane Katayama, Tadashi Uemura and Yukako Hattori
    • Organizer
      Kyoto Biomolecular Mass Spectrometry Society (KBMSS)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Nutrient-dependent responses of somatosensory neurons in Drosophila larvae: their underlying mechanisms and impacts on physiological functions2020

    • Author(s)
      Yasutetsu Kanaoka, Henrik Skibbe, Yusaku Hayashi, Koun Onodera, Ayumi Mure, Yuuki Takahash, Tadao Usui, Yukako Hattori, and Tadashi Uemura
    • Organizer
      Kyoto Biomolecular Mass Spectrometry Society (KBMSS)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Interspecies comparative analyses reveal distinct carbohydrate-responsive systems among Drosophila species2020

    • Author(s)
      Kaori Watanabe, Yasutetsu Kanaoka, Shoko Mizutani, Hironobu Uchiyama, Shunsuke Yajima, Masayoshi Watada, Tadashi Uemura, Yukako Hattori
    • Organizer
      Kyoto Biomolecular Mass Spectrometry Society (KBMSS)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 成長期の栄養履歴の違いがどのようにして寿命の差を生むか2020

    • Author(s)
      水谷 祥子、古谷 寛治、高橋 優喜、牟禮 あゆみ、服部 佑佳子、上村 匡
    • Organizer
      Kyoto Biomolecular Mass Spectrometry Society (KBMSS)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Interspecies comparative analyses reveal distinct carbohydrate-responsive systems among Drosophila species2020

    • Author(s)
      Kaori Watanabe, Yasutetsu Kanaoka, Shoko Mizutani, Hironobu Uchiyama, Shunsuke Yajima, Masayoshi Watada, Tadashi Uemura, Yukako Hattori
    • Organizer
      EMBO | EMBL Symposium "The Organism and its Environment"
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of nutrient-dependent responses of somatosensory neurons in Drosophila larvae: their underlying mechanisms and adaptive roles.2019

    • Author(s)
      Yasutetsu Kanaoka, Henrik Skibbe, Yusaku Hayashi, Koun Onodera, Ayumi Mure, Yuuki Takahashi, Tadao Usui, Yukako Hattori, and Tadashi Uemura
    • Organizer
      the 52nd annual meeting of the Japanese Society of Developmental Biologists (JSDB)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 個体成長を支える共生微生物の栄養基盤解明に向けて2019

    • Author(s)
      服部佑佳子
    • Organizer
      第21回生命科学研究科シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] The nutritional basis of Drosophila associated microbes for larval growth2019

    • Author(s)
      Ayumi Mure, Yuuki Takahashi, Masayoshi Watada, Toshihiko Katoh, Aina Gotoh, Takane Katayama, Tadashi Uemura, and Yukako Hattori
    • Organizer
      26th European Drosophila Research Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nutrient-dependent responses of somatosensory neurons in Drosophila larvae: their underlying mechanisms and impacts on physiological functions2019

    • Author(s)
      Yasutetsu Kanaoka, Henrik Skibbe, Yusaku Hayashi, Koun Onodera, Ayumi Mure, Yuuki Takahashi, Tadao Usui, Yukako Hattori, and Tadashi Uemura
    • Organizer
      26th European Drosophila Research Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Interspecies comparative analyses reveal distinct carbohydrate-responsive systems among Drosophila species2019

    • Author(s)
      Kaori Watanabe, Yukako Hattori, Yasutetsu Kanaoka, Shoko Mizutani, Hironobu Uchiyama, Shunsuke Yajima, Masayoshi Watada, Tadashi Uemura
    • Organizer
      26th European Drosophila Research Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 個体成長を支えるショウジョウバエ共生酵母・共生細菌の栄養基盤の解析2019

    • Author(s)
      Ayumi Mure, Yuuki Takahashi, Masayoshi Watada, Toshihiko Katoh, Aina Gotoh, Takane Katayama, Tadashi Uemura, and Yukako Hattori
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 感覚神経細胞における栄養応答の分子機構と個体生理機能に果たす役割の追究2019

    • Author(s)
      金岡 泰哲、Henrik Skibbe、林 優作、小野寺 孝興、牟禮 あゆみ、高橋 優喜、碓井 理夫、服部 佑佳子、上村 匡
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 成長期の栄養履歴の違いがどのようにして寿命の差を生むか2019

    • Author(s)
      水谷 祥子、古谷 寛治、高橋 優喜、牟禮 あゆみ、服部 佑佳子、上村 匡
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of nutrient-dependent responses of somatosensory neurons in Drosophila larvae: their underlying mechanisms and adaptive roles2019

    • Author(s)
      金岡 泰哲
    • Organizer
      第 3 回京都生体質量分析研究会シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] The nutritional basis of Drosophila associated microbes for larval growth2019

    • Author(s)
      牟禮 あゆみ
    • Organizer
      The 17th International Student Seminar
    • Related Report
      2018 Research-status Report
  • [Presentation] 頑健な代謝制御機構が支えるショウジョウバエ近縁種群の栄養環境への適応2019

    • Author(s)
      渡辺 佳織
    • Organizer
      定量生物学の会第9回年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Systemic TGFβ/Activin signaling underlies distinct dietary responses between generalist and specialist species2018

    • Author(s)
      渡辺 佳織
    • Organizer
      The 17th International Joint Mini-Symposium on Molecular and Cell Biology
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ショウジョウバエの成長を支える共生微生物の栄養バランス基盤の解析2018

    • Author(s)
      服部佑佳子
    • Organizer
      先進ゲノム支援 拡大班会議
    • Related Report
      2018 Research-status Report
  • [Presentation] Systemic TGFβ/Activin signaling governs adaptive metabolic responses to nutrient balances of Drosophila species2018

    • Author(s)
      Yukako Hattori, Kaori Watanabe, Yuuki Takahashi, Yasutetsu Kanaoka, Shoko Mizutani, Hironobu Uchiyama, Shunsuke Yajima, Masayoshi Watada, Tadashi Uemura
    • Organizer
      CDB Symposium 2018 “Dynamic Homeostasis: from Development to Aging”
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Systemic TGFβ/Activin signaling governs adaptive metabolic responses to nutrient balances of Drosophila species2018

    • Author(s)
      Yukako Hattori, Kaori Watanabe, Yuuki Takahashi, Yasutetsu Kanaoka, Shoko Mizutani, Hironobu Uchiyama, Shunsuke Yajima, Masayoshi Watada, Tadashi Uemura
    • Organizer
      京都生体質量分析研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Differential TGFβ/Activin signaling activity underlies distinct adaptive responses to nutrient balances between generalist and specialist Drosophila species2018

    • Author(s)
      Kaori Watanabe, Yukako Hattori, Yuuki Takahashi, Yasutetsu Kanaoka, Shoko Mizutani, Hironobu Uchiyama, Shunsuke Yajima, Masayoshi Watada, Tadashi Uemura
    • Organizer
      the 16th International Student Seminar
    • Related Report
      2017 Research-status Report
  • [Presentation] Deciphering regulatory mechanisms of distinct responses to nutrient balances between generalist and specialist species2018

    • Author(s)
      Kaori Watanabe, Yukako Hattori, Yuuki Takahashi, Yasutetsu Kanaoka, Shoko Mizutani, Hironobu Uchiyama, Shunsuke Yajima, Masayoshi Watada, Tadashi Uemura
    • Organizer
      CDB Symposium 2018 “Dynamic Homeostasis: from Development to Aging”
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Systemic signaling for distinct adaptive responses to nutrient balances between generalist and specialist species2017

    • Author(s)
      Yukako Hattori
    • Organizer
      MRC LMS/Kyoto University SPIRITS Program Workshop, MRC London Institute of Medical Sciences
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Systemic signaling for distinct adaptive responses to nutrient balances between generalist and specialist species2017

    • Author(s)
      Yukako Hattori, Kaori Watanabe, Yuuki Takahashi, Yuki Furumizo, Hironobu Uchiyama, Shunsuke Yajima, Masayoshi Watada, Tadashi Uemura
    • Organizer
      the 25th European Drosophila Research Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Yukako Hattori2017

    • Author(s)
      Systemic signaling for adaptation to nutrient balances in animal growth
    • Organizer
      Cell Biology, Developmental Biology, and Systems Biology Course Retreat
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 栄養バランス変化への適応能力を支える全身性シグナリング2017

    • Author(s)
      服部 佑佳子
    • Organizer
      第19回生命科学研究科シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] The molecular basis of distinct responses to nutrient balances between generalist and specialist species.2017

    • Author(s)
      Yukako Hattori
    • Organizer
      日本発生生物学会第50回大会
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Deciphering distinct responses to nutrient balances between generalist and specialist species by comparative multi-omics approaches2017

    • Author(s)
      Kaori Watanabe, Yukako Hattori, Yuuki Takahashi, Yuki Furumizo, Yasutetsu Kanaoka, Hironobu Uchiyama, Shunsuke Yajima, Masayoshi Watada, Tadashi Uemura
    • Organizer
      the 4th Asia-Pacific Drosophila Research Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The molecular basis of distinct adaptive responses to nutrient balances between generalist and specialist species2017

    • Author(s)
      Yukako Hattori, Kaori Watanabe, Yuuki Takahashi, Yuki Furumizo, Yasutetsu Kanaoka, Hironobu Uchiyama, Shunsuke Yajima, Masayoshi Watada, Tadashi Uemura
    • Organizer
      European Molecular Biology Laboratory Symposia "Metabolism in Time and Space: Emerging Links to Cellular and Developmental Programs"
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The molecular basis of distinct adaptive responses to nutrient balances between generalist and specialist species2017

    • Author(s)
      Yukako Hattori, Kaori Watanabe, Yuuki Takahashi, Yuki Furumizo, Yasutetsu Kanaoka, Hironobu Uchiyama, Shunsuke Yajima, Masayoshi Watada, Tadashi Uemura
    • Organizer
      The 3rd International Insect Hormone Workshop
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Deciphering regulatory mechanisms of distinct responses to nutrient balances between generalist and specialist species2017

    • Author(s)
      Kaori Watanabe, Yukako Hattori, Yuuki Takahashi, Yuki Furumizo, Yasutetsu Kanaoka, Hironobu Uchiyama, Shunsuke Yajima, Masayoshi Watada, Tadashi Uemura
    • Organizer
      the 25th European Drosophila Research Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 個体成長において栄養バランス変化への適応を支える全身性シグナル経路2017

    • Author(s)
      Yukako Hattori, Kaori Watanabe, Yuuki Takahashi, Yuki Furumizo, Yasutetsu Kanaoka, Hironobu Uchiyama, Shunsuke Yajima, Masayoshi Watada, Tadashi Uemura
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Remarks] 栄養に柔軟に適応し成長するシステムの解明 -種間の適応能力の差を生む炭水化物応答機構-

    • URL

      http://www.kyoto-u.ac.jp/ja/research/research_results/2019/190904_1.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] Why fruit flies eat practically anything

    • URL

      https://www.kyoto-u.ac.jp/en/research/research_results/2019/190904_1.html

    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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