Establishing "Architectural RNA" as a novel functional category of noncoding RNAs
Project/Area Number |
17K15084
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Functional biochemistry
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Research Institution | Kumamoto University (2018-2019) Hokkaido University (2017) |
Principal Investigator |
Chujo Takeshi 熊本大学, 大学院生命科学研究部(医), 特任助教 (50788578)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | architectural RNA / 核内RNA顆粒 / 難溶性RNA / Sam68 nuclear body / FABS / Architectural RNA / 長鎖noncoding RNA / prion-like domain |
Outline of Final Research Achievements |
This study, along with my successor's study, other lab members' studies, and my collaborator's studies have collectively enabled the establishment of "architectural RNA" as one functional category of long noncoding RNAs, which was the final goal of this study.
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Academic Significance and Societal Importance of the Research Achievements |
今世紀に発見された機能未知のnoncoding RNA (ncRNA) 群の内、核内顆粒の構造構築を司るncRNAをarchitectural RNA (arcRNA) として確立することができた。
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Report
(4 results)
Research Products
(16 results)
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[Presentation] Multiple NEAT1 modular RNA domains cooperatively construct phase-separated, distinct, highly ordered paraspeckle nuclear bodies2018
Author(s)
Tomohiro Yamazaki, Sylvie Souquere, Hiro Takakuwa, Hyura Yoshino, Takeshi Chujo, Archa Fox, Charles Bond, Shinichi Nakagawa, Gerard Pierron, and Tetsuro Hirose
Organizer
JAJ RNA 2018
Related Report
Int'l Joint Research
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