| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In the present project, we investigated the mechanisms underlying synthesis and regulation of cellular phospholipids and elucidated several new insights into them as follows: (i) A novel CL synthetic pathway was identified. The pathway was activated under low mitochondrial PE conditions. (ii) Ice2 was identified as the factor affecting the PE synthesis via a PS-decarboxylase, Psd1. Loss of Ice2 decreased the level of ER-resident form of Psd1, but not mitochondria-resident one. (iii) The novel role of mitochondrial outer membrane protein, Porin in mitochondrial phospholipid metabolism was revealed. It was further suggested that Porin was involved in the regulation of mitochondrial PE synthesis.
These findings would contribute to the understanding of homeostatic mechanism in cellular phospholipids.
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