| Project/Area Number |
17K15127
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
Akiyama Ryutaro 奈良先端科学技術大学院大学, 先端科学技術研究科, 助教 (00790403)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | クッペル胞 / 器官形成 / 器官サイズ / FGF / ロバスト性 |
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| Outline of Final Research Achievements |
In this study, we aimed to elucidate a novel type of organ robustness where the fluctuations of organ size are compensated at the functional level.Using the zebrafish Kupffer's vesicle as a model system, we performed simultaneous evaluation of organ size and function, and combined them with live imaging.We propose that the Kupffer’s vesicle maintains its function by fine-tuning the cilium property according to organ size.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で得られた成果は、生命が個体や器官の大きさをどのように制御・維持しているのかについて、特に機能との関連からその仕組みを考える上で、重要な知見となる可能性がある。また、本研究による器官サイズ制御機構の理解は、再生医療に必須な「器官の大きさを自由に操る技術」などの応用面への展開が期待される。
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