| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Brain insulin-producing cells (IPCs) play a key role in controlling reproductive dormancy in Drosophila. We found that IPCs in females raised under non-dormant condition acquire strong responsiveness to cold stimuli while IPCs in females raised under dormant condition do not. A gustatory receptor and a K2P channel were identified to be involved in the temperature response of IPCs which is observed in females raised under non-dormant condition. Furthermore, we found that the expression of insulin genes changes in IPCs depending on the breeding conditions. Together, these results suggest that IPCs adjust their membrane properties and insulin-gene expression depending on the environmental conditions. These features of IPCs would enable them to function as a key regulator of reproductive dormancy.
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