Mathematical and physiological basis for high S/N ratio of rod photoreceptors
| Project/Area Number |
17K15156
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 網膜 / 視細胞 / オプシン / シミュレーション / シグナル伝達 / パッチクランプ / マウス / 松果体 / 生理学 |
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| Outline of Final Research Achievements |
Vertebrate rod and cone photoreceptors are responsible for scotopic and photopic vision, respectively. The light sensitivity and kinetics of there photoreceptors differ depending on their vison. The relationship between photoresponse properties and the phototransduction pathways and morphology in both photoreceptor cells remains unclear. To clarify this, we have created mouse models in which phototransduction molecules in rods are replaced with red cone opsin. In addition, the spatial model of photoreceptor cells revealed that the differences in photoreceptor morphology are involved in the photoresponse characteristics.
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| Academic Significance and Societal Importance of the Research Achievements |
脊椎動物の視細胞の生理学的研究において、細胞に存在する分子の性質の違いに主眼がおかれ、形態の違いの重要性は考慮されない傾向にあったが、本研究により形態的違いが果たす役割について理論的に証明されたことは重要な意義がある。また、細胞の空間モデリングは任意の形態を構築できる為、視細胞だけでなく他の細胞にも応用可能であることから、今後様々な細胞において形態的要因が果たす役割が明らかになると期待される。
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Novel erythrocyte clumps revealed by an orphan gene Newtic1 in circulating blood and regenerating limbs of the adult newt2018
Author(s)
Casco-Robles Roman M., Watanabe Akihiko, Eto Ko, Takeshima Kazuhito, Obata Shuichi, Kinoshita Tsutomu, Ariizumi Takashi, nakatani Kei, Nakada Tomoaki, Tsonis Panagiotis A., Casco-Robles Martin M., Sakurai Keisuke, Yahata Kensuke, Maruo Fumiaki, Toyama Fubito, Chiba Chikafumi,
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Journal Title
Sci. Rep.
Volume: 8
Issue: 1
Pages: 7455-7455
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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