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Psysiological mechanism during sleep onset period that reflects subjective feeling of falling asleep

Research Project

Project/Area Number 17K15206
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied anthropology
Research InstitutionNeuropsychiatric Research Institute

Principal Investigator

Narisawa Hajime  公益財団法人神経研究所, 研究部, 研究員 (80763896)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords入眠期指標 / 自律神経活動 / NIRS / 脳の過覚醒 / 反復睡眠潜時検査 / 眠気の鈍麻 / 眠気評価の乖離 / 寝不足の慢性化 / マイクロスリープ / 入眠感 / 寝つき / 脳波 / 近赤外分光法 / 実験系心理学 / ストレス / 生理学 / 脳・神経 / 睡眠
Outline of Final Research Achievements

The number of participants who had a very short sleep latency was more than expected. Chronic sleep deprivation, which is a dominant problem in the younger generation, may also be a possible reason. Those people tend to show an apparent mismatch between objective sleep evaluation and subjective reports. They may not be accurately aware of their daytime sleepiness in daily life. In case of difficulty falling asleep, increasing sleep stages 1 and 2, sympathetic nerve activity, and OxyHb in specific channels were observed in addition to prolonged sleep latency. Although the NIRS index varied greatly among individuals, the results partially supported the hypothesis that frontal hyperwakeness is related to difficulty falling asleep. Especially in the condition like as sleep state misperception, evaluation based only on the R&K criteria is not sufficient, and difficulty in falling asleep may be detected by examination using more detailed indicators.

Academic Significance and Societal Importance of the Research Achievements

本研究は、入眠期の生理機構を多角的に検討することにより、起きているとも眠っているとも定義されない、半睡半醒である入眠期の意義と機構を理解するという試みであった。覚醒-入眠機構の遅延 (寝つきの悪さ) は不眠症の基本病態をなす。そのメカニズムを解明することで、より正確に入眠困難を判定し、治療介入効果の評価も可能となる。今後は注目した指標の組み合わせが臨床群でも応用可能かを検討する必要があるが、本研究は不眠症疾患の理解に大きく寄与するものであり、基礎から臨床研究までの幅広い領域への貢献が期待できるものと結論できる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (7 results)

All 2019 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] 入眠困難者の入眠期における生理心理学的指標の動態――脳波段階と自律神経活動の指標を用いて――2019

    • Author(s)
      成澤元、高橋敏治、八木朝子、千葉伸太郎、佐々木三男
    • Journal Title

      バイオフィードバック研究

      Volume: 印刷中

    • NAID

      130007807501

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 主観的眠気と客観的眠気の乖離する者にみられる睡眠と心身の特徴2019

    • Author(s)
      成澤 元、伊東 若子、木村 眞也、佐々木 かおり、 和田 真孝、安 正鎬、高橋 敏治、本多 真
    • Organizer
      日本睡眠学会第44回定期学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Characteristics of sleep structure among normal young adults with objective daytime sleepiness2019

    • Author(s)
      Hajime Narisawa
    • Organizer
      XVI Congress of the European Biological Rhythms Society (EBRS)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sleep and psychological characteristics of Japanese university students having daytime dysfunction2018

    • Author(s)
      Hajime Narisawa,Jungho Ahn,Toshiharu Takahashi
    • Organizer
      2nd of Asian Society of Sleep Medicine
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Psychological characteristics of Japanese university students having difficulty falling asleep2018

    • Author(s)
      Hajime Narisawa,Jungho Ahn,Toshiharu Takahashi
    • Organizer
      30th Association for Psychological Science Annual Convention
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] レム睡眠中の経頭蓋交流電流刺激を用いた明晰夢誘導実験2018

    • Author(s)
      成澤元、木村眞也、和田真孝、中村元昭、加藤進昌、伊東若子
    • Organizer
      日本睡眠学会第43回定期学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Sleep and psychiatric problems among university students classified into evening and intermediate chronotype2018

    • Author(s)
      成澤元, 安正鎬, 高橋敏治
    • Organizer
      第25回日本時間生物学会学術大会
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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