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The search for novel metabolites from microorganisms by physicochemical screening

Research Project

Project/Area Number 17K15250
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied microbiology
Research InstitutionKitasato University

Principal Investigator

Matsuo Hirotaka  北里大学, 北里生命科学研究所, 特任助教 (70613694)

Research Collaborator Hirose Tomoyasu  
Iwatsuki Masato  
Asami Yukihiro  
Nonaka Kenichi  
Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords天然物化学 / 新規有用物質 / 二次代謝産物 / 含窒素天然物 / 深海由来糸状菌 / 新規含窒素物質 / PC screening / 深海sijyoukinn / Sarcopodium属 / 細胞毒性 / 微生物利用学 / 微生物
Outline of Final Research Achievements

To obtain the useful novel metabolites, the physicochemical screening was carried out. Deep-sea derived fungal strains were used as a source. Five novel metabolites were obtained from three different fungi. These novel metabolites were found many useful activities and expected to be a seed compound such as medicines.

Academic Significance and Societal Importance of the Research Achievements

近年、科学技術の発展にともない、深海の探索が可能となってきた。そして、深海にも様々な生物が生存しており、糸状菌も多く存在していることが明らかになってきた。深海のような極限環境に適応するため、深海の糸状菌は陸上の糸状菌と異なる物質を生産していることが期待されている。
本研究により、深海の糸状菌は新規有用物質を生産していることが明らかとなり、今後、それらの物質が医薬品などに活用されることを期待したい。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (4 results)

All 2019 2018 2017

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] New metabolites, sarcopodinols A and B, isolated from deep-sea derived fungal strain Sarcopodium sp. FKJ-00252018

    • Author(s)
      Matsuo Hirotaka、Nonaka Kenichi、Nagano Yuriko、Yabuki Akinori、Fujikura Katsunori、Takahashi Yoko、Omura Satoshi、Nakashima Takuji
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 82 Issue: 8 Pages: 1323-1326

    • DOI

      10.1080/09168451.2018.1467264

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New metabolites, Sarcopodinols A and B, isolated from deep-sea derived fungal strain FKJ-00252018

    • Author(s)
      Matsuo H., Nonaka K., Nagano Y., Yabuki A., Fujikura K., Takahashi Y., Omura S., Nakashima T
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 印刷中

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 深海由来糸状菌 Penicillium sp. FKJ-0123 株が生産する新規シンナモイルトリペプチドについて2019

    • Author(s)
      松尾洋孝、目代貴之、野中健一、長野由梨子、矢吹彬憲、藤倉克則、庭野吉己、高橋洋子、大村智、中島琢自
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 深海由来糸状菌を探索源としたphysicochemical screening による新規物質の探索2017

    • Author(s)
      松尾洋孝、野中健一、長野由梨子、藤倉克則、高橋洋子、大村智、中島琢自
    • Organizer
      環境微生物系学会合同大会2017
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2020-03-30  

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