The search for novel metabolites from microorganisms by physicochemical screening
| Project/Area Number |
17K15250
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied microbiology
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| Research Institution | Kitasato University |
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Principal Investigator |
Matsuo Hirotaka 北里大学, 北里生命科学研究所, 特任助教 (70613694)
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| Research Collaborator |
Hirose Tomoyasu
Iwatsuki Masato
Asami Yukihiro
Nonaka Kenichi
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 天然物化学 / 新規有用物質 / 二次代謝産物 / 含窒素天然物 / 深海由来糸状菌 / 新規含窒素物質 / PC screening / 深海sijyoukinn / Sarcopodium属 / 細胞毒性 / 微生物利用学 / 微生物 |
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| Outline of Final Research Achievements |
To obtain the useful novel metabolites, the physicochemical screening was carried out. Deep-sea derived fungal strains were used as a source. Five novel metabolites were obtained from three different fungi. These novel metabolites were found many useful activities and expected to be a seed compound such as medicines.
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| Academic Significance and Societal Importance of the Research Achievements |
近年、科学技術の発展にともない、深海の探索が可能となってきた。そして、深海にも様々な生物が生存しており、糸状菌も多く存在していることが明らかになってきた。深海のような極限環境に適応するため、深海の糸状菌は陸上の糸状菌と異なる物質を生産していることが期待されている。
本研究により、深海の糸状菌は新規有用物質を生産していることが明らかとなり、今後、それらの物質が医薬品などに活用されることを期待したい。
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Report
(3 results)
Research Products
(4 results)
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[Journal Article] New metabolites, Sarcopodinols A and B, isolated from deep-sea derived fungal strain FKJ-00252018
Author(s)
Matsuo H., Nonaka K., Nagano Y., Yabuki A., Fujikura K., Takahashi Y., Omura S., Nakashima T
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 印刷中
Related Report
Peer Reviewed
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