| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
By comparing the chromosome structures of various Archaea species with different chromosomal proteins, we analyzed the differences in the principles of chromosome construction based on the combination of chromosomal proteins. The results showed that Archaea can be broadly classified into two groups: those with histones or HTa and a basic structure in which genomic DNA is wrapped around these proteins, and those without DNA wrapped around proteins. In addition, we proposed that TrmBL2 of hyperthermophilic Archaea has a function to repress gene expression at the time of foreign DNA acquisition (similar to that of bacterial H-NS). These results are important for considering the origin and evolution of chromosome structure in the three domains, including eukaryotes.
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