| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
An aim of this study is clarification of relationship of brain-gut interaction and energy metabolism effect of polymeric polyphenols. It was found that procyanidin as a polymeric polyphenol promote secretion of incretin hormone GLP-1 in plasma at light period administration. It was noteworthy that this promotion effect was differ from the administration timing. Moreover, procyanidin also changed the clock genes through increasing of GLP-1 secretion at light period. anti-hyperglycemic effect of CLPr was examined by an oral glucose tolerance test at different administration timings. CLPr administration at ZT1 significantly decreased postprandial hyperglycemia accompanied by promoting AMPK in skeletal muscle of mice. However, this effect could not observe at ZT13. These findings indicated that CLPr regulates clock gene expression through GLP-1, and the administration timing of CLPr affects its anti-hyperglycemic effect. Thus, CLPr regulates both circadian rhythm and metabolism.
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