| Project/Area Number |
17K15276
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
Kasakura Kazumi 東京理科大学, 基礎工学部生物工学科, 研究員 (00724577)
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | マスト細胞 / 腸内共生菌 / アレルギー / 腸管免疫 |
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| Outline of Final Research Achievements |
In this study, we found the following; ① Mast cells control the level of IgA which is important for protection against infection and the ratio of regulatory T cells (Treg) and CD103+DCs which are involved in the induction of Treg in the mesenteric lymph nodes. Moreover, mast cells play a critical role in the establishment of oral tolerance. ② Mast cell-dependent anaphylaxis was reduced in Germ-free and antibiotic-treated mice. It was shown that one of the mechanisms for this was the down-regulating of histamine receptor by commensal bacteria.
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| Academic Significance and Societal Importance of the Research Achievements |
マスト細胞は、アレルギー炎症を誘導する主たる細胞として知られているが、一方でアレルギー抑制に関わる制御性T細胞の割合を増加させ、その結果、食物アレルギー発症抑制に関わる「経口免疫寛容」誘導において重要な役割を果たすことを示した。このことから、マスト細胞はアレルギー炎症の増悪だけでなく抑制にも関わっていることを明らかにした。
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