Elucidation of the mechanisms by which intestinal microbiota control IgA synthesis in the large intestine and their application to immunomodulating functional foods
Project/Area Number |
17K15277
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Food science
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Research Institution | Nihon University |
Principal Investigator |
TSUDA Masato 日本大学, 生物資源科学部, 講師 (50525681)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Keywords | 腸内細菌 / 腸管関連リンパ組織 / IgA / Tfh細胞 / フラクトオリゴ糖 / 免疫グロブリンA(IgA) / 濾胞性ヘルパーT細胞 / 免疫グロブリンA(IgA) / MyD88 / レパトア / 大腸 / 免疫グロブリンA(IgA / 大腸免疫系 |
Outline of Final Research Achievements |
In this study, we analyzed the effect of intestinal microbiota on the induction of follicular helper T cells in the gut-associated lymphoid tissue from small and large intestine as well as intestinal and serum IgA production. Analysis from the mice maintained under different microbial environments showed that intracellular signaling and luminal factors which induce germinal center formation and Tfh cells in the gut-associated lymphoid tissue in the large intestine were different from those of the small intestine. Tfh cells from gut-associated lymphoid tissue of the large intestine had different T-cell receptor repertoire and mRNA expression from those of small intestine. Dietary fructo-oligosaccharides modulated the proportion and function of Tfh cells in cecal patches to enhance intestinal and serum IgA production.
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Academic Significance and Societal Importance of the Research Achievements |
本研究の成果は,小腸と大腸の免疫系細胞が腸内細菌により異なる調節を受ける機構の一端を明らかにした。これらの機構は,感染症や炎症反応などの予防や症状の緩和のために,プレバイオティクスなどの腸内細菌叢を調節する食品成分により大腸免疫系を制御するための新たな作用点となりうることが期待される。
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] A role for BATF3 in TH9 differentiation and T-cell-driven mucosal pathologies.2019
Author(s)
Tsuda M., Hamade H., Thomas LS., Salumbides BC., Potdar AA., Wong MH., Nunnelee JS., Stamps JT., Neutzsky-Wulff AV., Barrett RJ., Wang Y., Tang J., Funari VA., Targan SR., Michelsen KS.
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Journal Title
Mucosal Immunology
Volume: 12
Issue: 3
Pages: 644-655
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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