Dynamic analysis of hematopoietic stem cell development in the dorsal aorta
| Project/Area Number |
17K15393
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Integrative animal science
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Research Collaborator |
Fukuhara Shigetomo
Iida Atsuo
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 造血幹細胞 / 血管芽細胞 / インテグリン / ゼブラフィッシュ / 細胞接着分子 / 発生 / 血液 / 血管内皮細胞 |
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| Outline of Final Research Achievements |
In the present study, we have elucidated the role of integrins on hematopoietic stem cell development in the zebrafish embryo. Integrins are known to regulate not only cell adhesion but also signal transduction in many tissues. In this study, we determined, for the first time, the signaling pathway that regulates hematopoietic stem cell development.
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| Academic Significance and Societal Importance of the Research Achievements |
人工多能性幹細胞（iPS細胞）から造血幹細胞を造り出すためには、発生期における造血幹細胞の形成過程を分子レベルで解明する必要がある。ゼブラフィッシュは発生過程の細胞の動態を追跡しやすいなどの利点から発生生物学の分野で優れた実験モデルとして知られている。本研究で得られた知見は哺乳類でも共通である可能性が高く、今後、iPS細胞から造血幹細胞への分化誘導に応用できる可能性を秘めている。
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Report
(3 results)
Research Products
(2 results)
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[Journal Article] Rap1b promotes Notch signal-mediated hematopoietic stem cell development by enhancing integrin-mediated cell adhesion.2019
Author(s)
Rho S., Kobayashi I., Oguri-Nakamura E., Ando K., Fujiwara M., Kamimura N., Hirata H., Iida A., Iwai Y., Mochizuki N., Fukuhara S.
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Journal Title
Developmental Cell
Volume: 印刷中
Issue: 5
Pages: 1-16
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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