| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We examined the effects of stretch and angiotensin II on electrical spontaneous activity of pulmonary vein myocardium, which can be a risk factor for atrial fibrillation. In guinea pig isolated pulmonary vein tissue preparations, angiotensin II induced electrical spontaneous activity, which was suppressed by losartan (AT1 receptor antagonist), xestospongin C (IP3 receptor inhibitor) and SEA0400 (Na+/Ca2+ exchanger inhibitor). These results indicated that angiotensin II promotes the Ca2+ release from IP3 receptor via the AT1 receptor, which triggers the generation of electrical spontaneous activity of pulmonary vein myocardium by Na+/Ca2+ exchanger.
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