| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
The aim of this study was to determine whether treatment with an antioxidant or nitric oxide (NO) synthase inhibitor in combination with a calpain inhibitor provided more potent inner ear protection than treatment with a calpain inhibitor alone. The results showed that the combination treatment partially enhanced the inner ear protection effect compared with the single treatment, but to a less dramatic extent. As the cause, it was found that the inflammation reaction in the cochlea which is generated independently of oxidative stress and NO was possibly involved in the deafness disease state formation by the acoustic exposure.
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