Development of novel anti-methylmercuric drug based on oleanolic acid glucoside
| Project/Area Number |
17K15468
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | メチル水銀 / 抗メチル水銀薬 / サポニン化合物 / オレアノール酸サポニン誘導体 / サポニン誘導体 / 薬学 |
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| Outline of Final Research Achievements |
Oleanolic acid（OA) 3-ortoester was found as compounds exhibiting anti-methylmercury (MeHg) activity, in addition to OA 3-glucoside which has already been shown to exhibit anti-MeHg activity by suppressing mercury accumulation in organs.
OA 3-glucoside not only suppressed mercury accumulation in organs but also ameliorated motor dysfunction due to MeHg by supressing neuropathy caused by MeHg.
In addition, OA orthoester suppressed the accumulation of mercury in the organ under low concentration MeHg exposure condition.
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| Academic Significance and Societal Importance of the Research Achievements |
我々は食餌を介して微量ながらも絶えずMeHgにばく露し続けている。本研究で見出したOA3-グルコシドおよびOA3位オルトエステル体は、腸管におけるMeHgの吸収を抑制することで効果を発揮しているものと考えられ、日常的に摂取することで低濃度MeHgの影響を予防する効果も期待できる。これは、日常的に魚介類の摂食等によりばく露される量のMeHgが胎児へのリスクとなりうる妊婦において特に有効性が高いと考えられる。
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Report
(3 results)
Research Products
(5 results)
