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Discovery and mechanism of action of dimeric indole alkaloids with autophagy-regulating activity

Research Project

Project/Area Number 17K15472
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Natural medicines
Research InstitutionHoshi University

Principal Investigator

Nugroho Alfarius Eko  星薬科大学, 薬学部, 特任助教 (40770029)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsインドールアルカロイド / オートファジー / キョウチクトウ科 / 二量体モノテルペンインドールアルカロイド
Outline of Final Research Achievements

Eight new and 8 known monoterpene indole alkaloids were isolated from voacanga grandifolia、Leuconotis griffithii、Leuconotis eugenifolius and Tabernaemontana macrocarpa collected in Indonesia and Malaysia. The isolated compounds were tested for growth inhibitory activity against A549 (human lung adenocarcinoma), and 6 compounds isolated from Leuconotis griffithii and Voacanga grandifolia showed cell growth inhibitory activity.

Academic Significance and Societal Importance of the Research Achievements

従来、抗がん剤に期待される作用は、がん細胞にアポトーシス細胞死を誘導する効果であった。しかしながら、近年、アポトーシス耐性を持つがん細胞が知られており、新たな抗がん剤としてオートファジーを制御する物質の利用が注目されている。本研究により、新たなリード化合物が見出されることが期待される。また、作用機構の解明により新規標的分子の解明も考えられる。

Report

(3 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • Research Products

    (7 results)

All 2019 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (2 results) Remarks (1 results)

  • [Int'l Joint Research] University Malaya(マレーシア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] UIN Syarif Hidayatullah(インドネシア)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Leucophyllinines A and B, bisindole alkaloids from Leuconotis eugeniifolia2019

    • Author(s)
      Tang Yiming、Nugroho Alfarius Eko、Hirasawa Yusuke、Tougan Takahiro、Horii Toshihiro、Hadi A. Hamid A.、Morita Hiroshi
    • Journal Title

      Journal of Natural Medicines

      Volume: - Issue: 3 Pages: 533-540

    • DOI

      10.1007/s11418-019-01297-5

    • NAID

      40021912663

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bisleuconothines B-D, Modified Eburnane-Aspidosperma Bisindole Alkaloids from Leuconotis griffithii2018

    • Author(s)
      Nugroho Alfarius Eko、Zhang Wenjia、Hirasawa Yusuke、Tang Yiming、Wong Chin Piow、Kaneda Toshio、Hadi A. Hamid A.、Morita Hiroshi
    • Journal Title

      Journal of Natural Products

      Volume: 81 Issue: 11 Pages: 2600-2604

    • DOI

      10.1021/acs.jnatprod.8b00749

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] キョウチクトウ科Leuconotis eugenifoliusより単離した新規アルカロイドの構造と活性2018

    • Author(s)
      唐 怡鳴
    • Organizer
      日本生薬学会第65回年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] キョウチクトウ科Leuconotis griffithiiより単離した新規アルカロイドの構造と活性2017

    • Author(s)
      唐 怡鳴
    • Organizer
      日本生薬学会第64回年会
    • Related Report
      2017 Research-status Report
  • [Remarks]

    • URL

      http://polaris.hoshi.ac.jp/kyoshitsu/shouyaku/shouyaku.html

    • Related Report
      2018 Annual Research Report

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Published: 2017-04-28   Modified: 2020-03-30  

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