Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Outline of Final Research Achievements |
In this study, the impact of the CYP2D6 polymorphism on the effect of Tramadol was evaluated to explain the individual difference in analgesic. There are few genetic variants in which the activity of CYP2D6 is extremely decreased in Japanese people. However, even genetic polymorphisms in which the activity of CYP2D6 is slightly decreased, which, which are frequently observed in Japanese, significantly affect the efficacy of Tramadol.
|