| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
In Japan, curbing medical costs by preventing the progression of chronic kidney disease (CKD) has become a medical issue. In this study, we investigated the involvement of serine proteases in the enhancement of oxidative stress, which has been attracting attention as one of the factors that contribute to the progression of renal disorders. As a result, animal studies did not reveal the involvement of serine proteases. However, cultured cell experiments and in vitro experiments showed that oxidative stress might be regulated by serine proteases, suggesting that the FXa-PAR2 pathway is involved in one of them. Those results may serve as the basic information for elucidating the function of serine proteases in the progression of renal disorders and establishing new CKD therapeutic strategies.
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