Construction of novel CKD therapeutic strategy targeting oxidative stress regulation via serine protease
| Project/Area Number |
17K15509
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
Narita Yuki 熊本大学, 病院, 助教 (40614665)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | セリンプロテアーゼ / 酸化ストレス / 腎障害 |
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| Outline of Final Research Achievements |
In Japan, curbing medical costs by preventing the progression of chronic kidney disease (CKD) has become a medical issue. In this study, we investigated the involvement of serine proteases in the enhancement of oxidative stress, which has been attracting attention as one of the factors that contribute to the progression of renal disorders. As a result, animal studies did not reveal the involvement of serine proteases. However, cultured cell experiments and in vitro experiments showed that oxidative stress might be regulated by serine proteases, suggesting that the FXa-PAR2 pathway is involved in one of them. Those results may serve as the basic information for elucidating the function of serine proteases in the progression of renal disorders and establishing new CKD therapeutic strategies.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、セリンプロテアーゼを介し酸化ストレスが制御されている可能性を示した研究である。酸化ストレスは、腎障害進展機序の一因として以前から注目されており、抗酸化薬の腎疾患治療への応用が期待されている。本研究により、腎疾患における病態形成の共通基盤となる酸化ストレスに対するセリンプロテアーゼの関与が明らかとなり、CKD を含めた種々の腎疾患の病態解明や既存のセリンプロテアーゼ阻害薬を治療薬として応用するための基盤情報になると考えられる。新規治療薬が強く切望されているCKD に対し新たな治療戦略を提示することで、CKD の進展阻止による医療費の抑制に繋がる可能性がある。
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Doxycycline attenuates cisplatin-induced acute kidney injury through pleiotropic effects2018
Author(s)
Nakagawa T, Kakizoe Y, Iwata Y, Miyasato Y, Mizumoto T, Adachi M, Izumi Y, Kuwabara T, Suenaga N, Narita Y, Jono H, Saito H, Kitamura K, Mukoyama M
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Journal Title
Am J Physiol Renal Physiol
Volume: 315
Issue: 5
Pages: 1347-1357
DOI
Related Report
Peer Reviewed
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