Development of prevention/treatment system of diabetes targeting the DsbA-L gene
| Project/Area Number |
17K15510
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
Oniki Kentaro 熊本大学, 大学院生命科学研究部(薬), 助教 (00613407)
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| Research Collaborator |
SARUWATARI junji
JINNOUCHI hideaki
TSUJITA kenichi
OGATA yasuhiro
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| Project Period (FY) |
2017-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 糖尿病 / 肥満 / 非アルコール性脂肪性肝疾患 / モデリング / シミュレーション / DsbA-L / アディポネクチン / NAFLD / modeling & simulation / NONMEM |
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| Outline of Final Research Achievements |
Disulfide-bond A oxidoreductase-like protein (DsbA-L) is a key molecule in the multimerization of adiponectin (i.e. activation of adiponectin). In the present study, we investigated the effects of the DsbA-L gene on the risk of life-style related diseases. We clarified the influence of the DsbA-L rs1917760 polymorphism on the adiponectin multimerization and the relationship of the polymorphism with the weight status using prediction models based on a non-linear mixed effect model among elderly participants of a health screening program. Moreover, we indicated that the DsbA-L rs1917760 polymorphism was associated with the risk of chronic kidney disease using prediction models based on a non-linear mixed effect model among patients with type 2 diabetes.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、糖尿病に対する新規の予防・治療法の開発において、DsbA-Lが標的分子になり得ることを明らかにした知見であり、糖尿病の新規予防・治療法の開発に貢献するものである。また、本成果はモデリング&シミュレーションの手法を用いた独自の手法により、肥満や非アルコール性脂肪性肝疾患、糖尿病患者の慢性腎臓病に関する発症予測モデルの構築を試みた初めての知見でもあり、今後、様々な疾患への応用や医薬品の効果予測を組み込んだモデルへの拡張等、臨床での幅広い活用が期待される。
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] Modeling of the Weight Status and Risk of Nonalcoholic Fatty Liver Disease in Elderly Individuals: The Potential Impact of the Disulfide Bond-Forming Oxidoreductase A-Like Protein (DsbA-L) Polymorphism on the Weight Status.2018
Author(s)
Oniki K, Watanabe T, Kudo M, Izuka T, Ono T, Matsuda K, Sakamoto Y, Nagaoka K, Imafuku T, Ishima Y, Watanabe H, Maruyama T, Otake K, Ogata Y, Saruwatari J.
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Journal Title
CPT:Pharmacometrics & Systems Pharmacology
Volume: -
Issue: 6
Pages: 384-393
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association between oxidative stress-related genes polymorphisms and metabolic abnormalities among schizophrenia patients2017
Author(s)
Oniki K, Ishioka M, Osaki N, Sakamoto Y, Yoshimori Y, Tomita T, Kamihashi R, Tsuchimine S, Sugawara N, Otake K, Ogata Y, Saruwatari J, Yasui-Furukori N.
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Journal Title
Clinical Neuropsychopharmacology and Therapeutics
Volume: 8
Issue: 0
Pages: 25-37
DOI
NAID
ISSN
1884-8826
Related Report
Peer Reviewed
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[Journal Article] CYP2C19 variants and epoxyeicosatrienoic acids in patients with microvascular angina.2017
Author(s)
Akasaka T, Sueta D, Arima Y, Tabata N, Takashio S, Izumiya Y, Yamamoto E, Tsujita K, Kojima S, Kaikita K, Kajiwara A, Morita K, Oniki K, Saruwatari J, Nakagawa K, Hokimoto S.
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Journal Title
International journal of cardiology. Heart & vasculature
Volume: 15
Pages: 15-20
DOI
Related Report
Peer Reviewed
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[Presentation] Developing a Prediction Model to Clarify the Relationship between the BMI and the Risk for Nonalcoholic Fatty Liver Disease Based on a Modeling and Simulation Approach2017
Author(s)
Kentaro Oniki, Yuki Sakamoto, Miku Kudo, Tatsumasa Ono, Kazuki Matsuda, Narumi Muto, Tomoko Izuka, Takehisa Watanabe, Koji Otake, Yasuhiro Ogata, Junji Saruwatari
Organizer
American Diabetes Association's 77th Scientific Sessions
Related Report
Int'l Joint Research
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