| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The purpose of this study is to clarify the association with a protein binding rate of daptomycin or teicoplanin and qualitative changes of albumin in diabetes or chronic kidney disease, which have an increased prevalence as the population ages. We tried to develop measurement method of total and free daptomycin concentration and calculate the in vitro protein binding rate in assumed disease state of diabetes and chronic kidney disease. The wide range and high throughput method of total and free concentration for daptomycin using ultra-performance liquid chromatography coupled to tandem mass spectrometry was successfully developed. Furthermore, the examination of protein binding in the assumed disease state of diabetes and chronic kidney disease suggested that qualitative changes of albumin in these diseases did not affect the protein binding rate of daptomycin.
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