| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
To define the molecular mechanisms controlling the migration and differentiation of Muse cells, we evaluated migration ability of Muse cells using serum of mice with CCl4-induced acute hepatic injury. Muse cells exhibited higher migration ability compared with non-Muse cells. Furthermore, MicroRNA microarray analysis revealed that microRNAs changed expression in Muse cells following exposure on hepatitis serum. Effect of differential expressed microRNAs in Muse cells analyzed by introducing these microRNAs into Muse cells. These results established the basics of molecular mechanisms controlling the migration and differentiation of Muse cells.
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