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Searches for neurotransmitters in the spinal defecation center

Research Project

Project/Area Number 17K15557
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionKagoshima University

Principal Investigator

Naitou Kiyotada  鹿児島大学, 農水産獣医学域獣医学系, 准教授 (30794903)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords脊髄排便中枢 / 排便 / 消化管 / 脊髄 / 生理学 / 神経科学
Outline of Final Research Achievements

In this study, searches for the neurotransmitter, which acts in the spinal defecation center, were performed. As results, we found that serotonin, somatostatin, GABA and alpha-melanocyte-stimulating hormone act in the spinal cord and affect colorectal motility. We performed further investigations about effects of serotonin, somatostatin and alpha-melanocyte-stimulating hormone. These results were published as scientific papers and presented at academic conferences.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果から、脊髄排便中枢で作用する神経伝達物質が複数明らかになった。これまで知られていなかった、脊髄排便中枢で作用する神経伝達物質が明らかになったことで、脊髄排便中枢における排便制御メカニズムの一端が明らかになった。このことは、中枢神経系による排便制御の仕組みを解明するために必要な基礎的な情報を提供し、この分野の研究の進展に貢献するものだと考えている。また、本研究の成果は、ストレス性の腹痛や下痢など、中枢神経系が深く関わる排便障害の病態を解明するために必要となる、基礎的な情報を提供しており、社会的な意義も大きい。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (22 results)

All 2020 2019 2018 2017

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Analysis of the effect of intraspinal administration of alpha-melanocyte-stimulating hormone on colorectal motility.2020

    • Author(s)
      Hiromi UEDA, Mitsuya SHIRAISHI, Hiroyuki NAKAMORI, Takahiko SHIINA, Yasutake SHIMIZU, Kiyotada NAITOU
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 70

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of the noradrenergic nucleus locus coeruleus and dopaminergic nucleus A11 region as supraspinal defecation centers in rats.2019

    • Author(s)
      Nakamori H, Naitou K, Horii Y, Shimaoka H, Horii K, Sakai H, Yamada A, Furue H, Shiina T, Shimizu Y.
    • Journal Title

      Am. J. Physiol. Gastrointest. Liver Physiol.

      Volume: 317 Issue: 4 Pages: G545-G555

    • DOI

      10.1152/ajpgi.00062.2019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of peristaltic motility in the striated muscle portion of the esophagus using a novel in vivo method in rats2018

    • Author(s)
      Horii Kazuhiro、Shiina Takahiko、Naitou Kiyotada、Nakamori Hiroyuki、Horii Yuuki、Shimaoka Hiroki、Shimizu Yasutake
    • Journal Title

      Neurogastroenterology & Motility

      Volume: 31 Issue: 4

    • DOI

      10.1111/nmo.13518

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Descending monoaminergic pathways projecting to the spinal defecation center enhance colorectal motility in rats2018

    • Author(s)
      Naitou Kiyotada、Nakamori Hiroyuki、Horii Kazuhiro、Kato Kurumi、Horii Yuuki、Shimaoka Hiroki、Shiina Takahiko、Shimizu Yasutake
    • Journal Title

      American Journal of Physiology-Gastrointestinal and Liver Physiology

      Volume: 315 Issue: 4 Pages: G631-G637

    • DOI

      10.1152/ajpgi.00178.2018

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Muscarinic suppression of ATP-sensitive K+ channels mediated by the M3/Gq/11/phospholipase C pathway contributes to mouse ileal smooth muscle contractions2018

    • Author(s)
      Wang Ban、Murakami Yuri、Ono Maiki、Fujikawa Saki、Matsuyama Hayato、Unno Toshihiro、Naitou Kiyotada、Tanahashi Yasuyuki
    • Journal Title

      American Journal of Physiology-Gastrointestinal and Liver Physiology

      Volume: 315 Issue: 4 Pages: G618-G630

    • DOI

      10.1152/ajpgi.00069.2018

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Local regulatory mechanism to coordinate colorectal motility in rats2018

    • Author(s)
      Sawada Rika、Nakamori Hiroyuki、Naitou Kiyotada、Horii Kazuhiro、Horii Yuuki、Shimaoka Hiroki、Shiina Takahiko、Shimizu Yasutake
    • Journal Title

      Physiological Reports

      Volume: 6 Issue: 10 Pages: e13710-e13710

    • DOI

      10.14814/phy2.13710

    • NAID

      120007017306

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Medullary raphe nuclei activate the lumbosacral defecation center through the descending serotonergic pathway to regulate colorectal motility in rats.2018

    • Author(s)
      Nakamori H, Naitou K, Horii Y, Shimaoka H, Horii K, Sakai H, Yamada A, Furue H, Shiina T, Shimizu Y.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol.

      Volume: 314 Issue: 3 Pages: G341-G348

    • DOI

      10.1152/ajpgi.00317.2017

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Exogenous serotonin regulates colorectal motility via the 5-HT2 and 5-HT3 receptors in the spinal cord of rats.2018

    • Author(s)
      Nakamori H, Naitou K, Sano Y, Shimaoka H, Shiina T, Shimizu Y.
    • Journal Title

      Neurogastroenterol. Motil.

      Volume: 30 Issue: 3

    • DOI

      10.1111/nmo.13183

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Induction of hibernation-like hypothermia by central activation of the A1 adenosine receptor in a non-hibernator, the rat2018

    • Author(s)
      Shimaoka Hiroki、Kawaguchi Takayuki、Morikawa Kahori、Sano Yuuki、Naitou Kiyotada、Nakamori Hiroyuki、Shiina Takahiko、Shimizu Yasutake
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 68 Issue: 4 Pages: 425-430

    • DOI

      10.1007/s12576-017-0543-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Colokinetic effect of somatostatin in the spinal defecation center in rats.2017

    • Author(s)
      Naitou K, Shiina T, Nakamori H, Sano Y, Shimaoka H, Shimizu Y.
    • Journal Title

      J Physiol Sci.

      Volume: 印刷中 Issue: 3 Pages: 243-251

    • DOI

      10.1007/s12576-017-0524-1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] alpha-melanocyte-stimulating hormone(alpha-MSH)の脊髄内投与による排便促進作用の解析2020

    • Author(s)
      植田大海、白石光也、中森裕之、椎名貴彦、志水泰武、内藤清惟
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脊髄排便中枢におけるα-MSHによる大腸運動促進メカニズムの検討2019

    • Author(s)
      植田大海、白石光也、中森裕之、椎名貴彦、志水泰武、内藤清惟
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The mechanism of sexually dimorphic responses of colorectal motility by noxious stimulation in rats2019

    • Author(s)
      Kazuhiro Horii, Yuka Ehara, Kiyotada Naitou, Hiroyuki Nakamori, Takahiko Shiina, Yasutake Shimizu
    • Organizer
      9t FAOPS congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sex differences in the regulation of colorectal motility via descending pain inhibitory pathway in rats2018

    • Author(s)
      Kazuhiro Horii, Y. Ehara, K. Naitou, H. Nakamori, T. Shiina, Y. Shimizu
    • Organizer
      FNM 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ラットの下行性疼痛抑制経路を介した大腸運動制御における雌雄差2018

    • Author(s)
      堀井和広、江原優花、内藤清惟、中森裕之、椎名貴彦、志水泰武
    • Organizer
      第65回中部日本生理学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 侵害刺激による大腸運動の促進反応に性差がみられるメカニズムの解明2018

    • Author(s)
      堀井和広、江原優花、内藤清惟、中森裕之、椎名貴彦、志水泰武
    • Organizer
      第161回日本獣医学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] ラットの大腸運動を制御するモノアミン関連神経核2018

    • Author(s)
      中森裕之、内藤清惟、堀井和広、椎名貴彦、志水泰武
    • Organizer
      第60回日本平滑筋学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] ラットのモノアミン関連神経核による脊髄排便中枢を介した大腸運動制御2018

    • Author(s)
      中森裕之、内藤清惟、堀井和広、椎名貴彦、志水泰武
    • Organizer
      第28回日本病態生理学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] ラットの痛みによる大腸運動制御における脊髄内伝達物質の性差2018

    • Author(s)
      堀井和広、江原優花、中森裕之、内藤清惟、椎名貴彦、志水泰武
    • Organizer
      第28回日本病態生理学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Colokinetic effect of somatostatin on the spinal cord in anesthetized rats.2018

    • Author(s)
      Kiyotada NAITOU, Takahiko SHIINA, Hiroyuki NAKAMORI, Kazuhiro HORII, Yasutake SHIMIZU
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] identification of neurotransmitters acting on the spinal defecation center in rats.2017

    • Author(s)
      Kiyotada NAITOU, Hiroyuki NAKAMORI, Takahiko SHIINA, Yuuki SANO, Hiroki SHIMAOKA, Kazuhiro HORII, Yasutake SHIMIZU
    • Organizer
      The International Society for Autonomic Neuroscience 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脊髄排便中枢におけるソマトスタチンによる大腸運動亢進メカニズムの検討2017

    • Author(s)
      内藤 清惟、中森 裕之、堀井 和広、椎名 貴彦、志水 泰武
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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