| Project/Area Number |
17K15643
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Meguro Shiori 浜松医科大学, 医学部, 助教 (40724290)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | pericyte / 血管平滑筋細胞 / perivascular tumor / myosin 1B / Pericyte / 病理学 |
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| Outline of Final Research Achievements |
In our previous study, we identified myosin 1B (MYO1B) as a new pericyte marker, and we have reported that vascular mural cells were classified into three types of cells; α-SMA(+)/MYO1B(+)/hCD(-) pericytes, α-SMA(+)/MYO1B(-)/hCD(+) vascular smooth muscle cells, and α-SMA(+)/MYO1B(+)/hCD(+) vascular mural cells with intermediate features.
The aim of this study was the application of MYO1B to diagnostic pathology. We found a soft tissue tumor entirely composed of α-SMA(+)/MYO1B(+)/hCD(-) tumor cells, indicating that the tumor was a perivascular myoid tumor with definitive pericytic differentiation.
Furthermore, we reported a case of a nasal glomus tumor with diffuse and strong synaptophysin expression.
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| Academic Significance and Societal Importance of the Research Achievements |
MYO1BとhCDを組み合わせることで、ヒトホルマリン固定パラフィン包埋材料において、免疫組織化学的にpericyteへの分化を検討できるようになった。MYO1Bを診断病理学に応用し、皮下腫瘍および軟部腫瘍のpericyteへの分化を検討したところ、pericyteのみから構成されると考えられる腫瘍を見出し、報告することができた。
その他にも、鼻領域のsinonasal glomangiopericytomaなどpericyteへの分化を検討したい腫瘍において、MYO1Bは有用であると考えられる。
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