|Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|Outline of Final Research Achievements
Cancer cells show abnormal morphology, which is so-called “atypia”.Lamin is one component of nuclear envelope, and “lamin scar”, a novel phenomenon, was reported in recent years.Lamin scar is said to result from cancer cell invasion, and we aimed to uncover the mechanism and the relationship to atypia.We immunohistochemistrically analyzed the expression of lamin in invasive urothelial carcinoma, but there were no significant changes in shape and distribution of lamin in invasive cancer cells. Therefore, we next try to another candidate protein “microtubule associated protein 7 (MAP7)”, which is related to microtubule, a main component affecting cellular shape.In the same way, we immunohistochemistrically evaluated the expression of MAP7 in urothelial carcinoma, and there are significant changes related to nuclear polarity, grade, and invasion.Now, we are going to submit a paper, and analyze further its potentials in diagnostic aid and therapeutic predictive factor.