| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Methotrexate-associated lymphoproliferative disorders (MTX-LPDs) are disease, which exhibit various types of histology, and the definitive diagnostic criteria and histologic categories for MTX-LPDs are yet to be established. In this study, MTX-LPD lesions were classified into 4 diagnostic categories, and clinicopathologic features of reactive lymphoid hyperplasias (RHs), polymorphic LPDs (Poly-LPDs), diffuse large B-cell lymphomas (DLBCLs), and classic Hodgkin lymphomas (CHLs) were analyzed. Many features were significantly different among these histologic categories. After MTX withdrawal, progression-free survival (PFS) was the greatest for RH, followed by for Poly-LPD, DLBCL, and CHL. Furthermore, predictive factors for PFS were identified in each histologic category.
Current results indicate that histologic categorization and histology-specific factors could be useful for predicting MTXLPD progression after MTX withdrawal.
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