Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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Outline of Final Research Achievements |
I focused on molecules (proteins) that are specifically expressed in cancer. And I have collaborated to develop small-RNA for cancer-specific proteins as a cancer therapeutic drug (molecular target drug) that eliminates only cancer cells. As a result, a novel small-RNA different from the conventional structure was found, and I have analyzed the mechanism of gene expression regulation (RNA interference) by novel small-RNA. While it is suggested that the dependence of Dicer1 on gene expression regulation by this novel small-RNA differs greatly depending on the small-RNA, it seems to be highly dependent on Ago2 regardless of the type of this novel small-RNA.
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