| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Toxoplasma gondii (T. gondii) is an obligate intracellular parasite that causes toxoplasmic encephalitis in immunocompromised patients. To clarify the role of the adaptor molecule TRAF6 at astrocytes in T.gondii infection, we infected mice lacking TRAF6 in astrocytes with T.gondii and found no change in mortality or the number of parasites in the brain compared to the WT mice. In contrast, dendritic cell-specific TRAF6-deficient (CKO) mice died 11 days after infection.
These results suggest that T. gondii in CKO mice were increased above the acceptable range of mouse tissues due to Insufficient IFN-γ levels immediately after infection because increasing of IFN-γ levels associated with T. gondii infection was delayed.
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