| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
To clarify the mechanism of severe infection with Acinetobacter baumannii (A. baumannii) in aged hosts, we investigated immune responses in klotho KO mice after infection with A. baumannii. Klotho KO mice demonstrated high susceptibility to the infection. Additionally, the proportion of immune cells in the lungs of klotho KO mice infected with A. baumannii was altered compared with that in klotho WT mice infected with A. baumannii. This study suggests that alteration of immune responses in aged hosts induces severe infection of A. baumannii.
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