Role of pathogenic fungal mitophagy mitophagy in survival in host phagocytic cells.
| Project/Area Number |
17K15696
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
Nagi Minoru 国立感染症研究所, 薬剤耐性研究センター, 室長 (60711687)
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| Project Period (FY) |
2017-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | マイトファジー / Candida glabrata / 貪食細胞 / 好中球 / 病原性 / 酵母 / ミトコンドリア / オートファジー / 病原真菌 / カンジダ |
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| Outline of Final Research Achievements |
Although mitophagy in the pathogenic yeast Candida glabrata has been shown to be involved in pathogenicity, adaptation to the host environment, and maintenance of survival in an iron-deficient environment, its detailed role in these processes was not known. In this study, we show that CgATG32, a mitophagy essential gene in C. glabrata, is involved in survival in neutrophils.
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| Academic Significance and Societal Importance of the Research Achievements |
病原酵母Candida glabrataのマイトファジーは病原性や宿主体内環境における生存に関与しているが、その詳細は不明であった。本研究において、C. glabrataのマイトファジーに必須なCgATG32の遺伝子破壊株は、好中球と共培養した際の生存率が顕著に低下することが明らかになった。C. glabrataを含むカンジダ属の感染において重要なステップは、血中で好中球やマクロファージに貪食された後の生存である。感染における重要ステップにマイトファジーが関与していることが明らかになったことは、マイトファジーの新たな生理的役割の発見であり、CgATG32は真菌症の新たな治療標的となり得る。
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Report
(6 results)
Research Products
(24 results)
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[Journal Article] Prevalence of Candida bloodstream isolates from patients in two hospitals in Vietnam.2019
Author(s)
Bac ND, Anh LT, Quang LB, Luc NK, Nga TTT, Nagi M, Yoshitsugu M, Ha HTT, Anh DD, Quyet D, Anh DN.
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Journal Title
Iran J Microbiol.
Volume: 11(2)
Pages: 108-113
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] FK506 Resistance of Saccharomyces cerevisiae Pdr5 and Candida albicans Cdr1 Involves Mutations in the Transmembrane Domains and Extracellular Loops.2018
Author(s)
Tanabe K, Bonus M, Tomiyama S, Miyoshi K, Nagi M, Niimi K, Chindamporn A, Gohlke H, Schmitt L, Cannon RD, Niimi M, Lamping E.
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Journal Title
Antimicrobial Agents and Chemotherapy
Volume: 63
Issue: 1
DOI
Related Report
Peer Reviewed
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[Journal Article] Alleviation of lipopolysaccharide/d-galactosamine-induced liver injury in leukocyte cell-derived chemotaxin 2 deficient mice.2017
Author(s)
Okumura A, Saito T, Tobiume M, Hashimoto Y, Sato Y, Umeyama T, Nagi M, Tanabe K, Unoki-Kubota H, Kaburagi Y, Hasegawa H, Miyazaki Y, Yamagoe S.
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Journal Title
Biochemistry and Biophysics Reports
Volume: 12
Pages: 166-171
DOI
Related Report
Peer Reviewed / Open Access
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