| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The etiology of Interstitial cystitis/bladder pain syndrome (IC/BPS) is still not completely understood, and effective drug treatments have not been established. Therefore, we created chronic cystitis model which causes long-lasting bladder pain and overactive bladder in rats. We further tested the effect of gabapentin on those symptoms in a rat model of chronic cystitis. Gabapentin showed analgesic effects for bladder pain, and prevented the increased frequency of the voiding observed in chronic cystitis model. The results of this study indicated that gabapentin is effective on both symptoms in this chronic cystitis model.
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