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Y-90 Bremsstrahlung Imagingusing Compton Camera

Research Project

Project/Area Number 17K15798
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical Physics and Radiological Technology
Research InstitutionGunma University

Principal Investigator

Sakai Makoto  群馬大学, 大学院医学系研究科, 助教 (70727338)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsコンプトンカメラ / Y-90の / 制動X線 / 核医学 / 画像再構成 / コ ン プ ト ン カ メ ラ / Y-90 / イットリウム / イブリツモマブ チウキセタン / 放射線 / 医療・福祉
Outline of Final Research Achievements

The measurement was performed using a human body phantom. A high-speed image reconstruction method was also developed to reduce the calculation time. In this process, the influence of noise has become large in the reconstructed image, so a noise suppression filter was added to the image reconstruction algorithm. When the performance of the newly created image reconstruction program was evaluated by simulation, it was confirmed that an image of higher quality could be obtained while shortening the time required for image reconstruction. By combining these, the distribution of Y-90 could be imaged by Compton camera. Besides, comparing the measurement performance with the conventional equipment, it was confirmed that the spatial resolution is similar to the conventional scintillation camera (SPECT) can be obtained.

Academic Significance and Societal Importance of the Research Achievements

コンプトンカメラは一般的にγ線を測定するために用いられるが、β線源をイメージングできる可能性が示された。本研究の結果はY-90の体内動態を直接測定できる可能性を示すもので、将来の医療費抑制に大いに役立つ。またコンプトンカメラの医療応用に向けた画像再構成手法の開発を行ったことにより、核医学応用だけでなく、粒子線の飛程測定など近距離のコンプトンイメージングの性能を向上させることに成功した。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (16 results)

All 2020 2019 2018 2017 Other

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (9 results) (of which Int'l Joint Research: 6 results,  Invited: 1 results) Remarks (2 results)

  • [Journal Article] Improved iterative reconstruction method for Compton imaging using median filter2020

    • Author(s)
      Sakai Makoto、Parajuli Raj Kumar、Kubota Yoshiki、Kubo Nobuteru、Kikuchi Mikiko、Arakawa Kazuo、Nakano Takashi
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 3 Pages: e0229366-e0229366

    • DOI

      10.1371/journal.pone.0229366

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Compton imaging with 99mTc for human imaging2019

    • Author(s)
      Sakai Makoto、Kubota Yoshiki、Parajuli Raj Kumar、Kikuchi Mikiko、Arakawa Kazuo、Nakano Takashi
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 12906-12906

    • DOI

      10.1038/s41598-019-49130-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Annihilation gamma imaging for carbon ion beam range monitoring using Si/CdTe Compton camera2019

    • Author(s)
      Parajuli Raj Kumar、Sakai Makoto、Kada Wataru、Torikai Kota、Kikuchi Mikiko、Arakawa Kazuo、Torikoshi Masami、Nakano Takashi
    • Journal Title

      Physics in Medicine & Biology

      Volume: 64 Issue: 5 Pages: 055003-055003

    • DOI

      10.1088/1361-6560/ab00b2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vivo simultaneous imaging with 99mTc and 18F using a Compton camera2018

    • Author(s)
      Sakai Makoto、Yamaguchi Mitsutaka、Nagao Yuto、Kawachi Naoki、Kikuchi Mikiko、Torikai Kota、Kamiya Tomihiro、Takeda Shin’ichiro、Watanabe Shin、Takahashi Tadayuki、Arakawa Kazuo、Nakano Takashi
    • Journal Title

      Physics in Medicine & Biology

      Volume: 63 Issue: 20 Pages: 205006-205006

    • DOI

      10.1088/1361-6560/aae1d1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of number of views on cross-sectional Compton imaging: A fundamental study with backprojection2018

    • Author(s)
      Sakai Makoto、Parajuli Raj Kumar、Kikuchi Mikiko、Yamaguchi Mitsutaka、Nagao Yuto、Kawachi Naoki、Arakawa Kazuo、Nakano Takashi
    • Journal Title

      Physica Medica

      Volume: 56 Pages: 1-9

    • DOI

      10.1016/j.ejmp.2018.11.006

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Fundamental simulation calculation of dopamine transporter imaging with Compton camera2020

    • Author(s)
      Makoto Sakai, Yoshiki Kubota, Nobuteru Kubo, Raj Kumar Parajuli, Mutsumi Tashiro
    • Organizer
      International Society of Radiation Neurobiolog
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Three Dimensional Compton Imaging using C-shaped arm2019

    • Author(s)
      Sakai Makoto, Raj PARAJULI, Kikuchi Mikiko, Arakawa Kazuo, Nakano Takashi
    • Organizer
      第117回医学物理学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Carbon Ion Radiotherapy and Medical Physics at Gunma University2019

    • Author(s)
      Makoto Sakai
    • Organizer
      CJUMP2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Improvement of reconstruction algorithm for Compton camera2019

    • Author(s)
      M Sakai, R K Parajuli, Y Kubota, N Kubo, M Kikuchi, K Arakawa, and T Nakano
    • Organizer
      IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] On-Beam Imaging of 718 keV Prompt Gamma using Si/CdTe Compton Camera for Carbon Ion Beam2019

    • Author(s)
      Raj Kumar Parajuli, Makoto Sakai, Wataru Kada, Mikiko Kikuchi, Kazuo Arakawa
    • Organizer
      IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sakai Makoto, Raj PARAJULI, Kikuchi Mikiko, Arakawa Kazuo, Nakano Takashi2019

    • Author(s)
      Three Dimensional Compton Imaging using C-shaped arm
    • Organizer
      第117回医学物理学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Three-dimensional Y90 imaging with a commercial Compton camera2018

    • Author(s)
      Sakai Makoto, Raj PARAJULI, Kikuchi Mikiko, Arakawa Kazuo, Yamaguchi Mitsutaka, Nagao Yuto, Kawachi Naoki, Nakano Takashi, and Masami Torikoshi
    • Organizer
      第115回医学物理学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Yttrium-90 (β-emitter) imaging using Compton camera2017

    • Author(s)
      Makoto Sakai, Raj Kumar Parajuli, and Wataru Kada
    • Organizer
      GUMI 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Impact of number of views on cross-sectional Compton imaging2017

    • Author(s)
      Makoto Sakai, Raj Kumar Parajuli, Mikiko Kikuchi, Kazuo Arakawa, Mitsutaka Yamaguchi, Yuto Nagao, Naoki Kawachi, and Takashi Nakano
    • Organizer
      JKMP 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Remarks] 医療用コンプトンカメラの開発

    • URL

      https://sites.google.com/a/gunma-u.ac.jp/ghmc-sakai/

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
  • [Remarks] 医療用コンプトンカメラの開発

    • URL

      https://heavy-ion.showa.gunma-u.ac.jp/lab/2017research/compton.pdf

    • Related Report
      2018 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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