Development of patient-specific three-dimensional printed filter for improvement of dose distribution in boron neutron capture therapy
| Project/Area Number |
17K15800
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | Nagoya University |
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Principal Investigator |
Kamomae Takeshi 名古屋大学, 医学部附属病院, 病院助教 (60706282)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | BNCT / 三次元造形 / 3Dプリンタ / モンテカルロシミュレーション / 中性子計測 / 医学物理学 / 放射線 / 3D printing |
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| Outline of Final Research Achievements |
Boron neutron capture therapy (BNCT) is a selective therapy at the cell level, utilizing mainly thermal neutron interaction with boron-10 in tumor cells. Our final goal is to develop a system that enables dose optimization by optimally modulating the neutron beam for each patient, taking into consideration the target shape and location and the surrounding healthy tissues. This study aimed to develop the three-dimensional (3D) printed filter for modulating the neutron beam intensity. In this study, we employed the material jetting 3D printing system with a nanocomposite hydrogel that was jointly developed by our group. We succeeded in the development of the 3D printed filter that was composed mainly of water and had the characteristic of flexible and robust. In the experimental measurements and Monte Carlo simulations, the results were demonstrated that the filter contributed to modulate the neutron beam intensity and energy.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究においては、主として2つの挑戦的課題に取り組んだと言える。まずBNCTにおいて患者個別に中性子ビームを最適変調するという新しい治療戦略確立を目指して、3Dプリンタの適応を試みた。そして一般的3Dプリンタ材料はポリ乳酸樹脂やABS樹脂であり中性子反応断面積が小さく本用途には不向きであるため、研究代表者が共同開発を行っているナノコンポジットハイドロゲル立体造形技術を応用し、新規材料開発に取り組んだ。これらの研究成果は、BNCTの治療効果向上と有害事象低減に向けた技術革新に貢献すると共に、三次元造形技術分野やナノテクノロジー分野などの幅広い関連分野で大きなインパクトを与えるものである。
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Development of Three-Dimensional Printed Compensator for Improvement of Dose Distribution in Boron Neutron Capture Therapy: A Preliminary Study2019
Author(s)
Takeshi Kamomae, Yoshinori Sakurai, Masataka Oita, Takushi Takata, Tatsuya Niimi, Takashi Matsumura, Takuya Saito, Tomohiro Komada, Katsuhiko Kato, Yoshiyuki Itoh, and Shinji Naganawa
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Journal Title
Medical Physics
Volume: 46(6)
Related Report
Open Access
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[Presentation] Development of three-dimensional printed compensator for improvement of dose distribution in boron neutron capture therapy: A preliminary study2019
Author(s)
akeshi Kamomae, Yoshinori Sakurai, Masataka Oita, Takushi Takata, Tatsuya Niimi, Takashi Matsumura, Takuya Saito, Tomohiro Komada, Katsuhiko Kato, Yoshiyuki Itoh, and Shinji Naganawa
Organizer
61st AAPM Annual Meeting
Related Report
Int'l Joint Research
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[Presentation] Feasibility of novel thin bolus using tungsten functional paper for electron beam radiotherapy2018
Author(s)
Takeshi Kamomae, Hajime Monzen, Kazuma Sugita, Kuniyasu Okudaira, Morikazu Amano, Yoshihiro Kawai, Hiroshi Oguchi, Motoki Kumagai, Mariko Kawamura, Kazuhiro Ohtakara, Yoshiyuki Itoh, Shinji Naganawa
Organizer
18th Asia-Oceania Congress of Medical Physics (AOCMP) and 16th South-East Asia Congress of Medical Physics (SEACOMP)
Related Report
Int'l Joint Research
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[Presentation] An attempt to create a blood vessel model by 3D printer using a hydrogel2017
Author(s)
Tomohiro Komada, Takeshi Kamomae, Jun Ito, Hiroyasu Umakoshi, Ken Nagasaka, Masaya Matsushima, Kojiro Suzuki, Makoto Tsuduki, Takeshi Uemura, Takashi Matsumura, Yoshihiro Norikane, Tatsuya Niimi, Shinji Naganawa
Organizer
第46回日本IVR学会総会
Related Report
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[Book] Recent Advancements and Applications in Dosimetry2018
Author(s)
Lili Chen, C-M Charlie Ma, James Chun Lam Chow, Yi Hong Ong, Michele M. Kim, Timothy C. Zhu, Xiaofeng Zhu, Dandan Zheng, Yin Zhang, Victoria Y. Yu, Minsong Cao, Humza Nusrat, James Renaud, Arman Sarfehnia, Maria F. Chan, Benjamin Zwan, Peter B. Greer, Marek J. Maryanski, David V. Fried, Takeshi Kmaomae
Total Pages
372
Publisher
Nova Science Publishers, Inc.
ISBN
9781536137590
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